Health & Veritas

Howie and Harlan are joined by Ted Long, senior vice president of ambulatory care and population health at New York City Health + Hospitals, to discuss New York City’s remarkable success in providing care to its most vulnerable citizens. Harlan discusses the state of research into long COVID, including his own studies; Howie reports on the first round of drug-price negotiation under the Inflation Reduction Act.  Links: “Scientists look at the progress made toward understanding—and treating—long COVID” National Institutes of Health “NIH launches new initiative to study ‘Long COVID’” The Yale Paxlovid for Long COVID (PAX LC) Trial Internal tremors and vibrations in long COVID: a cross-sectional study “Burnout threatens primary care workforce and doctors' mental health” NYC Health and Hospitals: Housing for Health “NYC Health + Hospitals Wins Superbowl Of Reducing Blood Pressure Awards” “Over 5,000 Patients Have Worked With NYC Health + Hospital Community Health Workers, Who Address Patients’ Pressing Social Needs To Improve Their Health” The White House: Biden-⁠Harris Administration Announces First Ten Drugs Selected for Medicare Price Negotiation “Drugmakers Are ‘Throwing the Kitchen Sink’ to Halt Medicare Price Negotiations” “The 4 Arguments You Will Hear Against Drug Price Negotiation” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Zhenqiu Lin, senior director of analytics at Yale’s Center for Outcomes Research and Evaluation, to discuss how quality measures can make care more consistent and effective and improve outcomes for patients. Howie provides an update on research on repetitive head trauma among young football players; Harlan reports on new findings about the benefits of semaglutide for people with heart disease. Links: “Neuropathologic and Clinical Findings in Young Contact Sport Athletes Exposed to Repetitive Head Impacts” American Academy Of Pediatrics: “Tackling in Youth Football” “National Use and Effectiveness of β-Blockers for the Treatment of Elderly Patients After Acute Myocardial Infarction” “Twenty-Year Trends in Outcomes for Older Adults With Acute Myocardial Infarction in the United States” “Quality Measure Public Reporting Is Associated with Improved Outcomes Following Hip and Knee Replacement” “Novo Nordisk A/S: Semaglutide 2.4 mg reduces the risk of major adverse cardiovascular events by 20% in adults with overweight or obesity in the SELECT trial” “Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan look back on some of their favorite moments from the first 92 episodes of Health & Veritas. Featured episodes: Ania Jastreboff: The Revolution in Obesity Medication Josh Geballe: Turning Yale Innovation into Startups Anna Kaltenboeck: Untangling Drug Prices Akiko Iwasaki: Is Long COVID One Disease or Many? Perry Wilson: The Formula for Medical Misinformation Jeffrey Sonnenfeld: The CEO Whisperer Harlan Krumholz, This Is Your Life Megan Ranney: What’s Next for Public Health? Michael Alosco: The Toll of Repetitive Head Impacts Gil Addo: Building a Model for Virtual Specialty Care Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

In this special episode, Howie and Harlan are joined by Vivek Murthy, the 19th and 21st Surgeon General of the United States, and a graduate of the Yale School of Management and the Yale School of Medicine. Links: The Commissioned Corps of the U.S. Public Health Service CDC: Understanding the Opioid Overdose Epidemic “How Sleep Deprivation Impacts Mental Health” CMS: Delivering Services in School-Based Settings Vivek Murthy and Harlan Krumholz: “Participation in Cancer Clinical Trials Race-, Sex-, and Age-Based Disparities” U.S. Surgeon General’s Advisory: Our Epidemic of Loneliness and Isolation Surgeon General’s Advisory on E-cigarette Use Among Youth Vivek Murthy: “U.S. surgeon general: I am concerned about social media and youth mental health” Visions Worldwide Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Alan Friedman, chief medical officer at Yale New Haven Hospital, to talk about the organizational and cultural changes that the hospital has made to minimize medical errors and unprofessional behavior that harm patients. Howie reports on a Yale study showing a gap in excess deaths between Republicans and Democrats after the COVID-19 vaccine was introduced; Harlan discusses the continued problem of financial toxicity for patients, and a new study casting doubt on the effectiveness of “neuroprotective” diets. Links: “Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic” “State-Level Excess Mortality in US Adults During the Delta and Omicron Waves of COVID-19” “Incidence of adverse events and negligence in hospitalized patients: results of the Harvard Medical Practice Study” “To Err is Human: Building a Safer Health System” “The Safety of Inpatient Health Care” “We’re Already Paying for Universal Health Care. Why Don’t We Have It?” “Out-of-Pocket Annual Health Expenditures and Financial Toxicity From Healthcare Costs in Patients With Heart Failure in the United States” “Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Melissa Davis, a Yale radiologist and a graduate of Yale SOM’s MBA for Executives program, to discuss the ‘whoa’ moments and the weaknesses she has encountered using artificial intelligence to help interpret scans. Harlan reflects on the slow progress toward a healthcare system that rewards value rather than volume; Howie reports on new treatments for Alzheimer’s disease.  Links: “Robert F. Kennedy Jr. suggests covid was designed to spare Jews, Chinese people” “The Medicare Physician Fee Schedule and Unethical Behavior” “Vinod Khosla: Machines will replace 80 percent of doctors” “Affirmative action ruling raises concerns over impact on medical school diversity” Yale School of Management: MBA for Executives Sepsis DX, co-founded by Melissa Davis “Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial” “Editorial: Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Julius Chapiro to discuss advances in the use of machine learning and molecular imaging to understand and treat liver cancer and his work as the director of Yale’s Center for Minimally Invasive Therapies. Harlan reports on a medical journal paper that highlights positive outcomes while ignoring negative ones; Howie warns of the impact of private equity ownership of medical practices. Links: “MR Imaging Biomarkers for the Prediction of Outcome after Radiofrequency Ablation of Hepatocellular Carcinoma: Qualitative and Quantitative Assessments of the Liver Imaging Reporting and Data System and Radiomic Features” “Froedtert & the Medical College of Wisconsin - Liver Cancer Minimally Invasive Therapies” ”Predicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning” “Comparison of Existing Response Criteria in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using a 3D Quantitative Approach” “Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients” “Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients” “Monetizing Medicine: Private Equity And Competition In Physician Practice Markets” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Dawn Harris Sherling, an internist at Florida Atlantic University and the author of Eat Everything: How to Ditch Additives and Emulsifiers, Heal Your Body, and Reclaim the Joy of Food. Harlan provides an update on the dangers of the artificial sweetener aspartame; Howie reflects on the lessons from an outbreak of fungal meningitis linked to a plastic surgery clinic in Mexico.  Links: “The WHO is about to declare aspartame can cause cancer. Here’s why you should listen.” “Donald Rumsfeld and the Strange History of Aspartame” Dawn Harris Sherling: Eat Everything How to Ditch Additives and Emulsifiers, Heal Your Body, and Reclaim the Joy of Food Harvard School of Public Health: The Microbiome “5 Food Additives You Should Avoid” “The UN Decade of Nutrition, the NOVA food classification and the trouble with ultra-processing” CDC: All about your A1C “A Shadowy Industry Group Shapes Food Policy Around the World” CDC: Fungal Meningitis Outbreak Associated with Procedures Performed under Epidural Anesthesia in Matamoros, Mexico “Joan Rivers Died From Complication in Treatment, Officials Say” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Hil Moss, a graduate of Yale SOM and the Yale School of Public Health, to discuss her experience being diagnosed with breast cancer while a Yale student, the challenges facing cancer survivors after treatment, and the virtual clinic that she founded to help fill the void. Harlan reports on highly effective new obesity treatments on the horizon; Howie discusses the far-reaching effects of the Dobbs ruling, one year later.  Links: “Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA” American Diabetes Association: “American Diabetes Association Highlights Novel Agent Retatrutide which Results in Substantial Weight Reduction in People with Obesity or Type 2 Diabetes During Late Breaking Symposium” “Experimental Lilly pill, Mounjaro both lead to 15% weight loss in clinical trials” Hil Moss: About VivorCare: The First Virtual Cancer Survivorship Clinic Hil Moss: “Enough pink: We’re doing Breast Cancer Awareness Month all wrong” “Dobbs v. Jackson Women’s Health Organization (2022)” “A National Survey of OBGYNs’ Experiences After Dobbs” “Indiana board reprimands Dr. Caitlin Bernard over 10-year-old's abortion case” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Howie and Harlan are joined by Sejal Hathi, a physician, podcaster, and social entrepreneur who recently left a White House role to become New Jersey’s health officer. Harlan asks if ChatGPT’s imagination is a bug or a feature; Howie discusses the toll of motorcycle accidents and makes the case for helmet laws.  Links: “Exclusive: 42% of CEOs say AI could destroy humanity in five to ten years” “Artificial Hallucinations in ChatGPT: Implications in Scientific Writing” “Ikigai: A Japanese concept to improve work and life” Sejal Hathi at TEDWomen: Girls Helping Girls Nurture NJ: Combating New Jersey’s Maternal and Infant Mortality Crisis About Civic RX “Mandatory Bicycle Helmet Laws in the United States: Origins, Context, and Controversies” “Motorcycle Accident Statistics & Numbers For 2023” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.