Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • How wrinkle relaxers (toxins) work • Can wrinkle relaxers be used on all lines and wrinkles? • Can wrinkle relaxers be used on the body? • Do wrinkle relaxers prevent lines from forming / getting worse? • The in-clinic experience • What happens immediately after a treatment • Trends / dosage / the natural look • Protocols and advice • Myth-busting • Can you cleanse your face that night? • Skincare • Does exercise make it wear off more quickly? • Combining wrinkle relaxers with filler • Risks and challenges • Can it cause bags under the eyes / make these worse? • Lymphatic drainage • Safety and efficacy • Different brands (and industry issues) • Is there such a thing as a ‘clean’ toxin? • Finding the right practitioner • What happens if you suddenly stop using them? Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few studies – all the links are here (press ‘episode website’ for the full list): One study showed that botulinum toxin can boost levels of collagen in the skin (while it’s active in the skin): https://pubmed.ncbi.nlm.nih.gov/22742715/ Alastin’s post-procedure product is here: https://alastin.com/products/inhance-post-injection-serum A study conducted in 2012 found that toxin’s longevity increased by 30% in patients who took 50mg of zinc daily. Read more here: https://pubmed.ncbi.nlm.nih.gov/22453589/ In the UK, head to BCAM or BACN to find a reputable practitioner. A 2008 paper published in the Journal Of The European Academy of Dermatology showed that when you remove the wrinkles from a photo, a person is perceived as ten years younger than they really are, but when you remove the wrinkles AND even out the pigmentation, the person is perceived as almost 16 years younger. The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • Body positivity and personal choice • What causes cellulite? • The role of diet and exercise • Lotions and potions • Body brushing / lymphatic drainage • Clinic grade treatments and devices • What to do about stretch marks • Pockets of stubborn fat • Loose skin following pregnancy / weight loss • Body positivity influencers • A new technique pioneered by an American surgeon • Cellulite is very common and very normal! Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few studies – all the links are here (press ‘episode website’ for the full list): Dr. Sophie recommends: https://www.paulaschoice.co.uk/skin-smoothing-retinol-body-treatment/m5800.html https://bodyballancer.co.uk/ https://www.flaviamorellato.co.uk/ https://dimple-amani.com/pages/body She also discusses: https://www.healthline.com/health/cellfina Morpheus8 microneedling Venus Viva radiofrequency skin resurfacing Profound RF microneedling Profhilo Body AirSculpt at Elite Body Sculpture (Dr Aaron Rollins) Data is still emerging on acoustic wave therapy – here’s one study https://www.beamedtrading.com/wp-content/uploads/storz_aesthetics_pdf/Adatto_AWT__Volume_Reduction.pdf Meet Chessy King https://www.stylist.co.uk/people/chessie-king-instagram-influencer-body-positivity-love-your-body/274717 …and Danae Mercer https://danaemercer.com/ The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • Is it sensitivity or rosacea? • The symptoms of sensitivity (possible links to other issues) • The different types (and symptoms) of rosacea • The importance of managing symptoms asap • Fiona’s experience and how it cleared up • Perimenopause and the link with acne rosacea • Rosacea triggers • Will HRT help? • What causes rosacea? • A link between rosacea and a stomach bacteria • The role of stress • Rosacea skincare / product recommendations • Products labelled “hypoallergenic” • What to look for in a skincare range • Can you use acids? • Can you use retinoids? • Thoughts on SPF • Topical antibiotics • Ivermectin • Roaccutane • Low dose (oral) antibiotics • Laser treatment • Facials • Peels • LED light • Prescription creams for flushing • How muscle relaxants can help • Gut health and rosacea • Foods that could be a trigger • Make-up • Is taking skincare samples home…theft?! • Who is most prone to rosacea? • Darker skin types and rosacea Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few brands, ideas, studies and individuals – all the links are here (press ‘episode website’ for the full list): The cream Fiona was prescribed: https://www.mayoclinic.org/drugs-supplements/ivermectin-topical-application-route/side-effects/drg-20075441?p=1#:~:text=Ivermectin%201%25%20topical%20cream%20is,only%20with%20your%20doctor%27s%20prescription. Sophie’s On Stella article https://www.onstella.com/the-latest/dryness-itchiness/a-guide-to-rosacea-menopause-treatment/ Research that shows a possible link between rosacea and a bacteria called helicobacter pylori https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042414/ Sophie recommends: Revision Skincare Gentle Cleansing Lotion Meder Beauty Net-Apax Prebiotic Cleansing Mask The Byoma range https://byoma.com/uk/ CeraVe Hydrating Cleanser La Roche-Posay Toleriane range Sophie also recommended PHAs - Polyhydroxy acids NeoStrata’s Restore range Sophie talked about azelaic acid Sophie also flagged granactive retinoids She talked about Elizabeth Arden Retinol + HPR Ceramide cream Byoma’s Retinol oil with granactive retinoids Meder Beauty Red Apex Concentrate SkinCeuticals PhytoCorrective Serum Synchrorose by SkinMed La Roche-Posay’s Rosaliac Anti-Redness Intense Serum Obagi Hydrate Meder Beauty Salva Derm moisturiser Sente Ultranourishing Cream Heliocare Mineral Tolerance Fluid or their A-R Emulsion Intradermology Synergy 6 La Roche-Posay Anthelios SPF50+ The Vichy range of sunscreens This is the Sali Hughes article Fiona mentions: https://www.theguardian.com/fashion/2015/aug/29/rosacea-treatments-that-work-sali-hughes Clarins’ Sensitive Skin Beauty Repair Concentrate is mentioned Sophie mentions the Byonik laser https://illuminateskinclinic.co.uk/treatment/byonik-laser We do have clinical studies that show a link between gut health and rosacea – here’s one https://www.dermatologytimes.com/view/skin-microbiota-linked-with-systemic-disease-rosacea Lex Gillies on Insta is @talontedlex Try Oxygenetix's foundation Also… Rosalique 3 in 1 Anti-Redness Miracle Formula SPF 50 You could also try Avène Tinted Mineral Fluid SPF50+ The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr Sophie and Fiona discuss: • What causes alopecia? • Genetic hair loss • The role of dihydrotestosterone (DHT) • The role of diet and medications • Over-processing / styling • Traction alopecia / braids • Dyson’s new range of dryers and straighteners • The role of hormones: childbirth, (peri)menopause, PCOS • The role of stress • Trichotillomania • Hair loss caused by auto immune disease • The work of Angela Christiano • JAK inhibitors • The role of the immune system • Isolated white patches of hair / trauma / shock • Gut health (see study info below) • COVID and hair loss • Hair re-growth after chemotherapy • Treatments – including… • Minoxidil • Finasteride • Laser therapy • Home LED devices • PRP • Stem cell therapy • The Trichotest (advanced DNA testing) • Blood tests to check for micronutrient deficiencies • The Keravive by HydraFacial • Hair transplants • Biotin • Viviscal Hair Growth Supplements • Do hair growth shampoos work? • How often should we wash our hair? • Scalp massage • Products available • Olaplex and lilial (what we know so far) • Dr Sophie’s favourite hair products and hairdresser Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few brands, people, and studies – all the links are here (press ‘episode website’ for the full list): The Manta hairbrush Dyson’s range of products Luke Hersheson’s products Philip Kingsley’s Tricho 7 Scalp Drops More on the work of Dr Angela here: https://magazine.medlineplus.gov/article/close-to-home-nih-researcher-and-alopecia-patient-seeks-a-cure#:~:text=Treatment%20breakthroughs-,Dr.,But%20not%20all%20people. There have been reports linking hair loss to dust mites, cytomegalovirus, or Epstein-Barr virus – and the role of the microbiome. Read more: https://www.actasdermo.org/en-alopecia-microbiome-a-future-therapeutic-articulo-S1578219021001487 Dr Sophie offers: The Trichotest (advanced DNA testing) Calecim Professional stem cell therapy Viviscal Hair Growth supplements (has around 10 published clinical studies) She highly recommends https://giellygreen.co.uk/ in London – especially Jordan Favier Dr Sophie recommends: MONPURE’s Follicle Boost Hair Density Serum The K18 hair range Dr Sophie also mentions… KeraHealth that uses a patented technology ingredient Philip Kingsley's PK4 – a soya-based supplement Nue Co's hair growth supplement More on the Olaplex story here: https://www.bbc.co.uk/news/health-64662934 The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • New data on the link between poor sleep and poor health • What happened when the light bulb was invented • Bright light and the circadian rhythm • Burn-out / work / sleep deprivation • How much sleep we really need • Sleep deprivation and the skin / accelerated ageing • What is good sleep hygiene? • Caffeine • Alcohol • Evening exercise and cortisol • Body temp • Blue light / screen time / melatonin • Devices in the bedroom • Circadian rhythm • Night owls / morning larks • REM sleep • The Oura ring (+ Kim Kardashian + Gwyneth Paltrow on socials) • Sleep apps • Insight Timer’s sleep stories • Weighted blankets • Sunrise alarm clocks and other types of alarm • Sleep ear buds • Temp controlled mattresses • VR sleep head sets / Therabody Smart Goggles • Space masks • Sensate (+ the vagus nerve) • The Apollo wristband • Magnesium • CBD • Dreem Distillery • 5 HTP • Ashwagandha • The role of glycine • The availability of melatonin in the UK (versus the US) • Blue light / amber light / device use • The Dodow device • ASMR • Lofi ASMR • Coloured noises (white noise etc) • Nature / forest / rainfall sounds • Sleep and hormones • Progesterone • The DUTCH test • Silk pillowcases – and sleep lines / bed head • Napping – good for longevity • Dr. Sophie’s espresso nap hack! • Working night shifts • Jet lag • Black-out blinds • The Time shift app Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few studies – all the links are here (press ‘episode website’ for the full list): The link between good sleep and good health. Read more: https://medicine.yale.edu/news-article/poor-sleep-may-increase-markers-of-poor-brain-health-new-study-finds/#:~:text=Poor%20Sleep%20May%20Increase%20Markers%20of%20Poor%20Brain%20Health%2C%20New%20Study%20Finds,-January%2029%2C%202024&text=Sleeping%20too%20much%20or%20too,life%2C%20a%20new%20study%20suggests. How much sleep do we really need? Read more: https://www.sleepfoundation.org/how-sleep-works/how-much-sleep-do-we-really-need#:~:text=Most%20healthy%20adults%20need%20at,happy%2C%20healthy%2C%20and%20sharp. Napping and longevity. Read more: https://www.theguardian.com/science/2023/jun/20/short-daytime-naps-may-keep-brain-healthy-as-it-ages-study-says The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • What causes lines and wrinkles? • Peptides – a brief intro • Retinoids • Peptides – more info • How peptides work and the different types • Peptides v retinoids • x2 peptide creams Dr. Sophie loves • How peptide creams can work where injectables can’t • Ceramides (why it’s important) • Understanding the role of hyaluronic acid • AHAs and BHAs and other acids • Protecting the skin barrier (esp with acids / retinoids) • PHAs and bionic PHAs (gentler acids) • Bakuchiol (a gentler exfoliant) • Ceramide supplements • The data on peptides v retinoids • Alastin’s unique approach to skincare • Different peptides will do different things • Dr. Sophie’s recommendations • Is this product worth the huge TikTok hype? • Is there a ‘hero’ product out there?! • Product overwhelm / the choices available • How the medical brands work (versus big-name brands) • A brand working uniquely on peri-meno skin • Can you get away with using just skincare actives? • A focus on ageing healthily Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few brands, ideas, studies and individuals – all the links are here (press ‘episode website’ for the full list): A 2019 study on women over the age of 40 found that the topical application of peptides created "significant improvements in skin wrinkles" in just two weeks. Read more here: https://www.mdpi.com/1422-0067/21/1/73 Dr. Sophie recommends: Meder Beauty Mio Fix Revision Skincare Revox Line Relaxer [these next ones are mentioned later in the podcast but we’re putting all the recommendations in one place] Skin Better Science AlphaRet Overnight Cream (plus the eye version) Skin Better Science Interfuse Intensive Treatment LINES SkinCeuticals HA intensifier This is Indeed Labs’ best-seller with the snoxin that Dr. Sophie mentions https://indeedlabs.com/collections/fine-lines-wrinkles/products/snoxin-ii Vichy – Mineral 89 Medik8’s retinoids Dr. Sophie LOVES https://www.revisionskincare.co.uk/products/d-e-j-face-cream?gad_source=1&gclid=CjwKCAiAi6uvBhADEiwAWiyRdvi5K1-F5sxZHLRVvfOZp2A4MLXkx_PCLrAbHXKwmGLhLOrQXvT6AhoClxIQAvD_BwE Dr. Sophie mentioned two particular PHAs called gluconolactone and lactobionic acid (the latter derived from milk) – these are gentler alternatives to AHAs, BHAs, retinoids and even glycolic and salicylic acid. Bakuchiol is an antioxidant found in the leaves and seeds of the psoralea corylifolia plant. This is also an alternative to AHAs, BHAs, retinoids etc. This is the Alastin skincare technology Dr. Sophie mentioned: https://alastin.com/pages/trihex-ingredient Dr. Sophie responds to the hype re this product from The Ordinary https://theordinary.com/en-gb/argireline-solution-10-serum-100403.html?gad_source=1&gclid=CjwKCAiAi6uvBhADEiwAWiyRdhg0oHPH2QS-4-EzAp7_7jEKh1QUYWunkBW58Di58oHlZERfryTgCRoCEh8QAvD_BwE&gclsrc=aw.ds A quick guide from Elle UK on the different types of peptides https://www.elle.com/uk/beauty/skin/a45735491/peptides/ The brand Dr. Sophie mentions that has a unique action with oestrogen and MEP technology https://emepelle.co.uk/pages/the-science-of-emepelle-and-mep The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter The American Elle magazine article Fiona mentions: https://www.elle.com/beauty/makeup-skin-care/a43552346/what-is-profhilo/ Some of the brands Dr. Sophie offers include: Profhilo Croma PhilArt Volite (SKINVIVE in the USA) Viscoderm Hydrabooster (great for the forehead and around the mouth) Other brands Dr. Sophie offers: Sunekos (with amino acids) Sculptra Dr. Sophie personally uses Profhilo (inc on her decolletage) and polynucleotides around the eyes and she loves / uses Volite (inc. around her neck). Dr. Sophie talks about biostimulators for the body including Sculptra; Lanluma; and Lenisna. Some more useful information: https://drsophieshotter.com/everything-you-need-to-know-about-polynucleotides/ The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • The cause(s) of crow's feet • Crow's feet and…the role of muscle relaxing injections • Crow's feet and…the role of poly nucleotides and / or fillers • Crow's feet and…what devices can achieve • The cause(s) of bags under the eyes • Bags under the eyes and…hyaluronic acid fillers • Bags under the eyes and…what devices can achieve • Bags under the eyes and…budget / at-home remedies • Bags under the eyes and…the role of sleep • The cause(s) of dark circles • Dark circles and… eye creams • Retinoid-based eye creams (and other actives) • Dark circles and make-up hacks • Dark circles and…laser treatments • Dark circles and…chemical peels • Eye surgery • The results Dr. Sophie sees in clinic • Face lifts (in relation to the eyes) • The causes of puffiness around the eyes • Puffiness and… budget / at-home remedies • Puffiness and…eye creams • Dr. Sophie’s eye cream regime (and product recommendations) • How we sleep / pillow hygiene • Sunken eyes (and when to contact a GP) • Sunken eyes and…fillers • The importance of eye tests • An anecdote on why they’re so critical / emergency laser treatment • Droopy eye brows / eye lids • Droopy brows and…blepharoplasty surgery • Droopy brows and… ultrasound (and DATA) • Droopy brows and…muscle relaxing injections • Droopy brows and…fillers • Thread lifts (and why care is needed) • ‘Spocking’ / heaviness after muscle relaxing injections • Why some people aren’t suited to muscle relaxing injections • How hormones impact the eyes (lots of examples + tips) • Perimenopause and the eyes (lots of info + tips) • x2 more anecdotes – floaters + a bang to the head (delayed eye impact) • Things you can do at home • Lymphatic drainage • How to use eye creams • Supplements – and data • Carrots and vitamin A • How to look after your eyes • Screen time / sunglasses / sleep Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few brands, ideas, studies and individuals – all the links are here (press ‘episode website’ for the full list): Bobbi Brown has a range of colour correctors – match to your shade then apply concealer on top: https://www.bobbibrown.co.uk/product/14018/15905/makeup/face-and-cheek/corrector-and-concealer/corrector#/shade/Light_Bisque Dr. Sophie’s eye routine: In the morning: She alternates between https://shop.illuminateskinclinic.co.uk/product/revox-line-relaxer-20ml/ OR https://shop.illuminateskinclinic.co.uk/product/myo-fix-frown-control-concentrate-15ml/ Then she’ll use https://shop.illuminateskinclinic.co.uk/product/d%c2%b7e%c2%b7j-eye-cream/ on top of either of the above. At night: https://www.skinbetter.com/shop-skincare/product-category/eye-care/eyemax-alpharet-overnight-cream-M009.html#tab=description There are studies to say that sleeping on your back is better. If that feels uncomfortable, try a medical-grade pressure-release pillow, like the Envy pillow. https://www.envypillow.com/ Dr. Sophie recommends: https://ziipbeauty.com/products/ziip-halo https://www.flaviamorellato.co.uk/ In one study, Vitamin E has been shown to help reduce the onset of cataracts – read more here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051399/#:~:text=Vitamin%20E%20is%20a%20lipid,membranes%20(12%2D15). There have been several studies on some of the B Vitamins which have shown their benefit to eye health. Especially Vitamin B12, Vitamin B9 and Vitamin B6. These may play a role in conditions such as AMD (age-related macular degeneration), this was highlighted in the Women’s Antioxidant and Folic Acid Cardiovascular Study (WAFACS). Thiamine (also known as Vitamin B1) has been shown to reduce and slow down the rate of developing cataracts. Omega 3 oils have been shown to be effective in treating dry eyes by helping the natural production of a healthy tear film. Lutein and zeaxanthin are the only dietary carotenoids found in the retina. According to a 2006 study, people who consume a diet that’s low in lutein and zeaxanthin may be at a higher risk for developing cataracts. https://pubmed.ncbi.nlm.nih.gov/16936087/ According to a 2016 study, lutein may help reduce dry eye symptoms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800098/ Vitamin A - along with beta carotene - has been studied in relation to reducing the development of cataracts and AMD. This is the brand Fiona uses (as recommended by her optician) https://www.boots.com/hycosan-extra-preservative-free-eye-drops-7-5ml-10172236 Dr Sophie mentioned this laser treatment https://lumenis.co.uk/vision/products/optilight/ Studies show there’s been an increase in myopia in children since COVID. It’s thought this is because of increased screen time and children developing a focal plane that’s only close up. Read more: https://bjo.bmj.com/content/early/2021/07/15/bjophthalmol-2021-319307 The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • What is regenerative aesthetics? • New data - ageing skin releases inflammatory mediators into the bloodstream • NEW - treatments that stimulate collagen and elastin • Harmonyca – how it goes beyond traditional fillers / bio stimulators • Bio stimulators – an explainer • NEW - devices that stimulate collagen and elastin • Sofwave • Radiofrequency micro-needling • The role of collagen supplements • NEW injectable – polynucleotides – stimulates stem cells • Juvalook – hyaluronic acid and PDLLA – and the eyes • NEW – gene therapy (and early-stage trials) • NEW – stem cell therapy (and products) • Human stem cells skincare versus plant ‘stem cell’ skincare • Growth factors as ‘stem cells’ in plant-based products • Synthetic products • What do human-based stem cell skincare products actually contain? • How many of the treatments are permanent? • What about downtime? • NEW - using exosomes in skincare • Exosomes – an explainer • Studies on exosomes – how they can regenerate skin and hair growth • Exosomes – topical versus injectables • Exosome skincare brands • South Korea – stem cell banking • NEW – how wrinkle relaxers are evolving • NEW – skincare ingredients to look out for • Sunflower sprout extract – how it works • Skincare that changes how a cell behaves • Dr Sophie’s go-to product • NAD+ as a skincare ingredient • How best to biohack your skin • Dr Sophie’s skincare protocols • Skincare with vitamin C and niacinamide • The role of sleep • The treatments Dr Sophie has • Skincare trends • ‘Prejuvenation’ • Body-care • High-performing plant-derived active ingredients • Microbiome-based skincare • Sustainability in skincare – formulations and packaging • Suncare innovations • AI in aesthetics (robots that inject wrinkle relaxers) • How AI can enhance the industry • The importance of human expertise • Neuro-glow (and mental health) Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few brands, ideas, studies and individuals – all the links are here: First, this is the Harpers Bazaar article that Dr Sophie contributed to: https://www.harpersbazaar.com/uk/beauty/a46114525/2024-beauty-trends/ There are several studies that indicate how ageing skin releases inflammatory mediators into the bloodstream – here’s one example: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082169/ https://drsophieshotter.com/harmonyca-is-this-injectable-the-future-of-fillers/ https://juvelook.uk/ (Dr Sophie later talks about results here with the eye area) https://lenisna.uk/ More on the new types of filler (e.g. PLLA and PCL) here: https://drsophieshotter.com/what-is-a-collagen-stimulating-filler/ https://www.sculptrausa.com/ https://ellanse.com/ https://radiesse.com/how-it-works/ Dr Sophie uses >> https://sofwave.com/ https://inmodemd.com/workstation/morpheus8/ https://candelamedical.com/products/profound/ https://cutera.co.uk/secretRF#:~:text=secrectRF%20%7C%20Non%2DSurgical%20Facial%20Resurfacing%20%7C%20CUTERA (Secret RF) Dr Sophie uses >> https://candelamedical.com/products/matrix/ https://drsophieshotter.com/everything-you-need-to-know-about-polynucleotides/ Dr Sophie uses >> https://www.cromapharma.com/uk/about-croma/press-and-downloads/croma-pharma-further-strengthening-its-portfolio-with-biostimulators/ Studies on exosomes include: https://www.sciencedirect.com/science/article/abs/pii/S1389172323003262 (hair) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296902/ (skin) Dr Sophie uses >> https://aestheticmanagementpartners.com/exo-e/ (EXO-E) Also mentioned > https://en.drsturm.com/exoso-metic-face-serum/ https://morphiya.com/ On sunflower sprout extract >> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622016/#:~:text=The%20sunflower%20seed%20and%20sprout,%2C%20and%20vitamins%20%5B2%5D. Dr Sophie uses >> https://www.revisionskincare.co.uk/products/d-e-j-daily-boosting-serum%E2%84%A2 Dr Sophie uses >> https://nuchido.com/blogs/news/meet-dr-nichola-conlon-the-founder-of-nuchido The Swedish sleep study https://www.bmj.com/content/341/bmj.c6614 Some brands mentioned: https://luna-daily.com/ https://www.biojuve.co.uk/ https://www.laroche-posay.co.uk/ https://go.redirectingat.com/?id=127X618962&url=https%3A%2F%2Fdcypher.me%2F&xs=1&xcust= (Dcypher – AI-powered foundation brand) https://renude.co/ - AI-trained to identify a range of skin concerns The skincare platform https://klira.skin/ offers epigenetic skin typing. The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.

Dr. Sophie Shotter Dr. Sophie and Fiona discuss: • Vit C and liposomal delivery • Vit C as a therapeutic supplement • The link between Vit C and collagen • Vit C and telomeres • Vit D and MS / long COVID • Types of vitamin D (and taking with vitamin K) • Magnesium (inc the link with stress / good sleep) • B vitamins – challenges with a plant-based diet • B12 and mental health • Omegas • Alpha-ketoglutarate • Ashwagandha (and stress) • CBD • Glutathione • MCT – the brain and memory • Creatine • Amino acids • Black cohosh and red clover (HRT alternatives?) • Women who’ve had breast cancer • Phyto-oestrogens • Milk thistle • St. John's wort • Spermidine • NAD+ • Resveratrol • Smart drugs (nootropics) • L-theanine and the brain / creativity (+ calming impacts?) • Bacopa Monnieri and memory • Curcumin and quercetin (and cancer) • Berberine • Iodine • Charcoal Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Dr Sophie and Fiona mention a few brands, ideas, studies and individuals – all the links are here: Supplement / brands mentioned and used / recommended by Dr Sophie… https://www.surreycentrefornaturalhealth.com/evernutri-supplements.html https://www.altrient.com/ https://www.allergyresearchgroup.com/vitamin-d3-complete-veggie-softgels/ https://www.metagenics.com/omegagenics-epa-dha-1000 https://oxfordhealthspan.com/#:~:text=Recommended%20by%20world%2Dleading%20longevity,concentrated%20Japanese%20wheat%20germ%20extract. https://nuchido.com/pages/nad-supplements https://timehealth.co.uk/product/ca-akg/ https://dreemdistillery.co.uk/ https://otowellbeing.com/pages/spa https://strongnutrients.com/products/pure-creatine?variant=36449563508901 https://www.symprove.com/ (probiotics not mentioned in this ep as it was covered in December but this is the brand Sophie always recommends) Other stuff including further reading and studies… Dr. Sophie’s Get The Gloss article: https://www.getthegloss.com/health/live-longer-tips-sophie-shotter The link between vitamin C and collagen https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-C#:~:text=Specifically%2C%20vitamin%20C%20has%20been,response%20to%20photodamage%20(48) Studies on therapeutic vitamin C: https://www.imperial.nhs.uk/about-us/news/latest-remap-cap-results https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295384/ https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02134-y https://www.frontiersin.org/articles/10.3389/fnut.2023.1025936/full Studies on therapeutic vitamin D: https://www.mssociety.org.uk/research/explore-our-research/emerging-research-and-treatments/vitamin-d https://www.theguardian.com/lifeandstyle/2021/jan/10/does-vitamin-d-combat-covid https://www.thelancet.com/journals/landia/article/PIIS2213-8587(18)30265-1/fulltext#:~:text=Our%20findings%20suggest%20that%20vitamin,lower%20doses%20of%20vitamin%20D. Magnesium and anxiety https://www.healthdirect.gov.au/blog/can-magnesium-help-to-reduce-anxiety#:~:text=The%20good%20news%20is%20that,calming%20effect%20on%20the%20body. Oxford study on B12 deficiency in male vegans https://www.bdi.ox.ac.uk/publications/65908 B12 deficiency and mental health / depression / dementia https://pubmed.ncbi.nlm.nih.gov/35337631/#:~:text=Vitamin%20B12%20deficiency%20can%20have,screening%20of%20at%2Drisk%20populations. A good article on omegas (inc. advice for those on a plant-based diet) https://www.vogue.in/beauty/content/what-do-you-really-need-to-look-for-in-your-omega-3-supplement The link between omega 3’s, mood, and cognitive function https://bmjopen.bmj.com/content/9/6/e027167 Metformin as a supplement https://fortune.com/well/2023/05/04/metformin-anti-aging-longevity-risks-side-effects/ The Bradley Cooper film discussed is https://en.wikipedia.org/wiki/Limitless_(film) This is an interesting supplement (NOTE: not tried or verified by Dr Sophie): https://www.wildnutrition.com/products/pure-strength-omega-3 And this is also an interesting supplement (NOTE: not tried or verified by Dr Sophie) https://www.thenakedpharmacy.com/products/saffrosun-calm-1 Info on ashwagandha: https://www.healthline.com/nutrition/ashwagandha#safety-and-side-effects This is an interesting supplement with both ashwagandha and magnesium (NOTE: not tried or verified by Dr Sophie) https://lifearmour.co.uk/products/super-me-capsules One of many CBD studies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/#:~:text=At%20the%20first%20monthly%20assessment,in%20anxiety%20and%20sleep%2C%20respectively. This is an interesting CBD alternative with PEA (NOTE: not tried or verified by Dr Sophie) https://youthandearth.com/collections/cbd-alternative/products/pea-60-capsules?variant=43663716679893 Lots of great info and resources on fasting and autophagy are online via Dr. Mindy Pelz - get googling! Coconut oil contains numerous MCTs and this has been shown in an older in-vitro study to reduce the growth of Candida (which causes thrush) by 25%. MCT has also been shown to have antimicrobial and antifungal effects. Some researchers suggest it might have certain anti-inflammatory effects, but more studies are needed. Read more here: https://www.healthline.com/nutrition/mct-oil-benefits#TOC_TITLE_HDR_2 In one study, people who supplemented with 8 grams of creatine per day for five days reduced mental fatigue during mathematical calculations, compared to those taking a placebo. Similarly, a review of 6 studies found that 5–20 gram doses could improve short-term memory. Info on creatine loading https://www.menshealth.com/nutrition/a28339030/creatine-loading/ Plus read https://www.womenshealthmag.com/uk/fitness/strength-training/a42178665/creatine/ Text that follows below is from this article: https://drsusanloveresearch.org/alternatives-to-hrt-complementary-care/ A study found that 70% of postmenopausal women who took 40mg black cohosh for 12 weeks reported a decrease in menopausal symptoms, including hot flashes but was no placebo group to compare this with and it was only 150 women taking part. The question for breast cancer survivors is whether it is estrogenic. On this front we actually have some data. Firstly, there’s no known phytoestrogen in black cohosh – and there’s no evidence that black cohosh binds to the estrogen receptor. In a petri dish, breast cancer cells were exposed to black cohosh in the absence of estrogen, in the presence of estrogen, and in the presence of tamoxifen. They found that the black cohosh given alone inhibited cell growth. When estrogen was added it blunted the growth usually seen and it enhanced the effects of tamoxifen. This effect has been replicated in four other studies on cell lines. Studies in women have confirmed this lack of estrogenic effect. NOTE: The Cancer Research UK site tells us you shouldn’t take black cohosh if you: • have breast cancer • have liver or kidney problems • have blood pressure problems or take medicines for your blood pressure • are pregnant or breastfeeding • And it lists several meds so do check with your GP or look at their website Red Clover is another commonly used herb marketed for hot flashes and menopausal symptoms. There have been two randomized controlled studies comparing it to placebo but neither study found that red clover was better than the placebo. There is concern about its ability to stimulate breast cancer, but this has not been studied. Some research suggests that St John's wort works in a similar way to standard antidepressant medication, by increasing the activity of brain chemicals such as serotonin and noradrenaline (thought to play an important part in regulating our mood). But some research suggests that it can make feelings of anxiety worse for some people. Experiences vary from person to person and more research needs to be done. Milk thistle info: https://www.healthspan.co.uk/advice/body/the-effects-of-milk-thistle-on-the-menopause/ L-Theanine firstly is a naturally occurring amino acid found in tea, but it can also be taken as a supplement. L-theanine is even more effective when taken with caffeine and taking even just 50 mg — the amount found in roughly two cups of brewed tea — has been found to increase alpha-waves in the brain, which are linked to creativity. Several studies have also shown that taking 200 mg of L-theanine has a calming effect, without causing drowsiness. Bacopa monnieri is a herbal supplement that has been shown to improve memory and information processing when taken for several months. Panax ginseng root is an ancient medicinal plant used to boost brain function. Taking a single dose of 200–400 mg of Panax ginseng has been shown to reduce brain fatigue and significantly improve performance on difficult tasks like mental math problems. Some longer-term studies have found that your body may adapt to ginseng, making it less effective after several months of use. So more research is needed on its long-term nootropic effects. This supp is interesting https://youthandearth.com/collections/anti-aging/products/preservage?variant=36505456738467 (NOTE: not tried or verified by Dr Sophie) Info on Jane McLelland and her approach to cancer (she used various supplements but also off-licence meds) – mentioned by Fiona – this is for information only (not endorsed by Dr Sophie) https://www.lifeextension.com/magazine/2020/1/wellness-profile Iodine. This brand talks about the fact that (quoting) “recent research shows the UK is one of just two high-income countries with iodine deficiency issues, and has a worse rate than some developing countries. This is largely linked to diet and poor intake of iodine rich foods (white fish, dairy and seaweeds of the right kinds).” – here is its range: https://doctorseaweed.com/collections/supplements (NOTE: not tried or verified by Dr Sophie) This is also interesting https://youthandearth.com/collections/improved-skin-complextion/products/irish-sea-moss-bladder-wrack?variant=43757230948565 (NOTE: not tried or verified by Dr Sophie) The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.