Know Your Physio

In this illuminating solo episode, I dive deep into the interconnected realms of applied physiology and neuroscience to explore how honoring our evolutionary design can transform the way we live, perform, and thrive. With a focus on bridging the gap between the world within us and the rapidly evolving modern world around us, I break down the fundamental principles of how our bodies and brains are designed to function under "normal conditions"—a concept that feels increasingly distant in today’s fast-paced, convenience-driven lifestyle.From the role of intermittent fasting in tapping into evolutionarily conserved mechanisms to the power of hormetic stressors like exercise, cold exposure, and mindful breathing, this episode unpacks how intentional, evidence-based lifestyle choices can support neuroplasticity, resilience, and overall well-being. I emphasize the importance of understanding key biomarkers like heart rate variability (HRV) to track and optimize our nervous system's adaptability and share actionable insights to help you integrate progressive, sustainable practices that elevate both mental clarity and physical performance.Whether you're navigating a health plateau, looking to build healthier habits, or simply aiming to deepen your connection with your body and mind, this episode offers a practical roadmap to reclaiming control over your physiology and psychology. Join me as I reflect on my own journey from dependency on external solutions to achieving self-mastery through a deeper understanding of how our bodies are designed to thrive in an ever-changing world.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Key Points From This Episode:Gap between modernity and physiology [00:01:06] Intermittent fasting and longevity [00:04:50] Heart rate variability and stress [00:09:21] Neuroplasticity and mental health [00:14:12]  Visit KYP Blog:https://knowyourphysio.org/learnSupport the show

In this insightful solo episode, I take a deep dive into one of the most pressing challenges of our modern age—managing our phone use. As we welcome a new year, it's the perfect time to reflect on how we spend our most precious resource: time. Through actionable advice and personal anecdotes, I explore the often-overlooked impact of excessive screen time and its ripple effects on our productivity, relationships, and overall well-being. This episode is all about reclaiming control and using technology intentionally to enrich, not detract from, our lives.From turning off non-essential notifications to curating a minimalist home screen, I share practical strategies that have transformed the way I interact with my phone. Drawing on my own experiences with ADHD and the challenges of staying focused in a hyper-connected world, I offer tools and techniques to reduce distractions, enhance presence, and cultivate meaningful connections. I also highlight powerful apps like One Sec and Opal, as well as lesser-known hacks to make your phone a tool for growth rather than a source of constant interruption.This episode is a call to action for anyone looking to break free from the cycle of mindless scrolling and instant gratification. Together, we’ll explore the importance of boredom, the value of delayed gratification, and how intentional phone use can lead to a more fulfilling and purpose-driven life. Tune in for a fresh perspective on managing your tech habits and starting 2025 with clarity, mindfulness, and focus. Let’s take back our time and use it to become the best versions of ourselves.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode:[00:00:24] Managing phone use intentionally.[00:05:35] Managing phone addiction effectively.[00:11:21] Importance of being bored.[00:13:45] Delayed gratification over instant pleasure.Apps:One SecA mindfulness app designed to interrupt impulsive phone use and promote intentional behavior. Mentioned as a highly recommended tool to manage screen time and reduce distractions.OpalAn app that helps block distractions and improve focus by managing app usage and promoting mindfulness.Support the show

In this thought-provoking episode, I have the pleasure of hosting Dr. Chris Rhodes, the CEO and Co-Founder of Mimio Health. A trailblazer in the field of biomimetics and regenerative health, Dr. Rhodes shares his groundbreaking research on fasting, longevity, and tapping into the body’s evolutionarily conserved mechanisms. With years of expertise and a passion for pushing the boundaries of human biology, he unveils how his work is redefining health optimization for the modern world.Our conversation dives deep into the science behind fasting and the revolutionary approach of biomimetic supplementation. Dr. Rhodes explains how Mimio Health's innovative formulation recreates the benefits of a 36-hour fast, activating metabolic pathways to enhance cellular health, longevity, and resilience—all without caloric restriction. From understanding the role of key metabolites like spermidine and nicotinamide to exploring the intersections of fasting, exercise, and mental clarity, this episode offers a masterclass in harnessing the power of biology to thrive in today’s environment.This episode is a must-listen for anyone curious about unlocking their body’s innate potential for healing and renewal. Dr. Rhodes’ insights shed light on how fasting mimetics can improve everything from metabolic health to biological age, while also empowering listeners to take charge of their own well-being. Whether you’re new to fasting or looking to optimize your health with cutting-edge science, this conversation will leave you inspired to explore what’s possible when we align with the natural brilliance of our biology. Tune in and take the first step toward unlocking your full potential!Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode:Evolutionarily preserved mechanisms [00:00:11]Fasting and longevity research [00:08:06]Hormetic stress and fasting benefits [00:12:00]Psychological benefits of fasting [00:16:00]Alternate day fasting benefits [00:21:23]Fasting mimetic supplement Mimio [00:37:09]Exercise and regenerative mechanisms [00:45:06]Autophagy activation by spermidine [00:47:01]Appetite suppression and metabolism [00:54:16]Exogenous ketone esters in formulations [01:01:13]Power of self-healing [01:09:08]PeopleDr. Chris RhodesLinkedInOfficial WebsiteDave PetrinoLinkedInBooks and ReferencesElegans ResearchResource on C. elegansSpermidine and AutophagyResearch Article: Study on Spermidine and AutophagyHormetic Stress MechanismsNIH Resource: Hormesis in BiologySupport the show

In this empowering solo episode, I dive deep into the science of carbohydrates and their profound impact on mental and physical performance. As your host, Andres Preschel, I share actionable insights on how to harness the power of carbohydrates by considering factors like glycemic index, timing, and exercise intensity. This episode is designed to help you understand the crucial role of carbs in fueling your body and mind while dispelling myths around carb phobia.I break down the art of tailoring your carbohydrate intake to your activity levels, explaining how to maintain steady energy, optimize exercise performance, and avoid the pitfalls of hyper- or hypoglycemia. Through relatable analogies and real-life strategies, I guide you on how to adapt your nutrition to match your daily demands, ensuring both stability and peak performance throughout your day.Whether you’re seeking to elevate your workouts, sustain mental clarity, or refine your nutritional habits for longevity, this episode is a practical roadmap to using carbohydrates as a powerful tool for health optimization. Tune in to learn how to make carbs work for you and achieve your highest potential in all aspects of life!Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode:Carbohydrates as efficient fuel source. [00:01:10] Carbohydrate glycemic index explained. [00:05:17] Meal timing and carbohydrate intake. [00:09:10] Andrés PreschelLinkedIn ProfileInstagram (@andrespreschel)Twitter (@andrespreschel)Official Website:knowyourphysio.orgPersonal Website:andrespreschel.comSupport the show

In this insightful episode, I am joined by Chris Mirabile, a visionary in the field of longevity and the founder of Novos, a company at the forefront of combating aging through science-backed strategies and natural innovations. Chris shares his personal journey of health challenges and triumphs, which led him to a lifelong commitment to understanding the science of aging and optimizing human potential. His mission to bridge the gap between cutting-edge biotech and accessible health solutions has made him a trailblazer in the field of longevity.Our conversation dives deep into the 12 hallmarks of aging, a revolutionary framework for understanding the biological mechanisms behind the aging process.  We also explore actionable lifestyle changes and the synergistic role of nutrition, supplements, and mindfulness in enhancing healthspan and lifespan. From the potential of senescent cell management to the transformative power of personalized health strategies, Chris provides valuable insights for anyone seeking to live a longer, healthier, and more vibrant life. Tune in to uncover the secrets to slowing aging and unlocking your full potential.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode: Health transformation through adversity [00:01:22]Health transformation through adversity [00:05:06]Defining aging at the cellular level [00:09:41]Novos Longevity Diet Optimization [00:12:29]Nutrient inadequacies in modern diets [00:17:04]Testing for vitamin levels [00:20:29]Iron levels and health risks [00:24:51]12 hallmarks of aging [00:29:22]Cellular senescence and longevity [00:31:51]Fasting mimetics and longevity [00:35:54]Trace doses of lithium benefits [00:39:44]Telomere shortening and lifespan [00:45:10]Stem cell exhaustion and aging [00:48:17]Microbiome dysbiosis and health [00:51:31]Synergistic effects of formulas [00:56:48]Lifestyle strategies affecting aging [01:03:12]Nervous system's impact on supplements [01:06:07]Longevity accessibility for everyone [01:10:34]Slowing down aging [01:12:17] SlowMyAgeWebsiteNovos LabsWebsiteNovos Life AppFree mobile app available on iOS and Android, featuring a biological age test, personalized lifestyle guidance, and integrated LLM (AI-powered guidance).PeopleChris MirabileLinkedIn ProfileInstagram (@slowmyage)Andrés PreschelLinkedIn ProfileInstagram (@andrespreschel)Twitter (@andrespreschel)Dan BuettnerWikipediaBlue Zones Official WebsiteSupport the show

In this episode, I’m stepping into the guest seat as Drew Shuman and I dive into the science and strategies behind optimizing health and performance. We explore how personalized practices, evidence-based biohacking, and a deeper understanding of your own physiology can transform your approach to well-being. This conversation is packed with actionable insights to help you take charge of your health journey.We cover a wide range of topics, including the cognitive and physical benefits of creatine, the role of carbohydrates in performance, and how to maximize VO2 max through strategic training. Drew and I discuss the importance of aligning your habits with your unique needs, demystifying complex health concepts, and providing practical advice for anyone looking to elevate their physical and mental performance.This episode is a must-listen for those curious about the intersection of science and health optimization. Whether you’re starting your journey or looking for advanced strategies, you’ll find plenty of inspiration and tools to create lasting change. Tune in to learn how to unlock your potential and embrace a healthier, more energized life.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://calendly.com/andrespreschel/intro-call-with-andresLinks Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode:VO2 max and longevity [00:05:28]Energy currency of the body [00:09:02]Carbohydrate consumption and performance [00:13:39]Ketogenic diet benefits and concerns [00:15:05]Carbohydrates and exercise benefits [00:21:03]Glycemic index and exercise timing [00:23:16]Leptin signaling and obesity cycle [00:29:16]Fasted training effectiveness [00:30:48]Carbohydrate intake for performance [00:35:45]VO2 max and training adaptations [00:39:41]High altitude training benefits [00:42:19]Creatine: Evolving perceptions and benefits [00:48:07]Muscle gain versus fat loss [00:56:07]Creatine's impact on mood [00:59:22]Managing light exposure for sleep [01:00:41]Morning hydration and sunlight [01:05:02]Neuroplasticity and personal transformation [01:09:36]Leveraging physiological mechanisms for health [01:11:17]PeopleDrew ShumanInstagramPlacesLongevity Center, West Palm BeachOfficial WebsiteGreenfield Water SolutionsOfficial WebsiteEveryday Dose CoffeeProduct WebsiteRelight Electrolytes by Redmond Real SaltProduct WebsiteSupport the show

In this compelling episode, I sit down with Dr. Benjamin Kosubevsky, an innovative expert in integrative medicine and detoxification therapies. As a specialist in heavy metal detoxification and hyperoxygenation treatments, Dr. Kosubevsky is transforming the way we approach chronic health issues tied to toxic exposures. His mission at the Longevity Center is not only to improve patient health but to make cutting-edge therapies like chelation and Eboo available and affordable for everyone, empowering individuals to tackle the environmental challenges impacting modern wellness.Our conversation delves into Dr. Kosubevsky’s deep-rooted passion for alternative medicine and his journey from traditional medical training to the pioneering, hands-on work he does today. He shares insights into the mechanics of chelation and hyperoxygenation, revealing how they remove accumulated heavy metals, reduce inflammation, and support whole-body healing. This episode is essential listening for anyone navigating fatigue, brain fog, or chronic inflammation, or simply curious about innovative paths to optimal wellness. Tune in to explore the profound potential of therapies that help restore the body’s natural resilience and discover how to take control of your own health journey.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://calendly.com/andrespreschel/intro-call-with-andresLinks Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode:Hyperoxygenation benefits for health [00:07:27]Mercury's impact on health [00:12:51]Molybdenum deficiency and heavy metals [00:14:37]Selenium's role in mercury protection [00:21:33]Foods that help chelate mercury [00:22:42]Hemochromatosis and iron levels [00:26:39]Mercury and neurological health impacts [00:30:01]Bioaccumulation of heavy metals [00:38:28]Ozone treatment advancements [00:46:41]Cost-effective chelation treatments [00:51:25]Vaccines and heavy metals [00:54:48]Heavy metals in everyday products [00:57:15]Chelation and oxygen benefits [01:02:18] PeopleDr. Benjamin KosubevskyLinkedIn ProfileInstagramDr. Wesley SmithUniversity of Miami ProfilePlacesLongevity CenterOfficial WebsiteProducts and ReferencesEDTA Chelation TherapyWebMD ResourceDMPS Chelation TherapyDMPS ChelationIV Ozone TherapyInformative ArticleSpirulina and Chlorella SupplementsInformative ArticleHyperoxygenation TherapyInformative Article:Molybdenum Deficiency and MercuryResearch ArticleSupport the show

In this compelling episode, I sit down with Eli Wininger, an ultramarathon runner, former IDF Special Forces commander, and a profound advocate for resilience and purpose. Known for his feats of endurance, Eli’s journey takes us from the battlefield to the grueling landscapes of ultramarathons, revealing the depth of his mental and physical fortitude. His latest achievement—a 251-mile race in Moab dedicated to each of the hostages taken on October 7th—demonstrates how he channels his experiences into a mission much larger than himself.Our conversation delves into the mindset of an endurance athlete and the emotional significance behind Eli’s relentless pursuit of challenges. Eli opens up about the importance of finding a powerful "why" to fuel our actions, whether that be through personal growth, health, or setting an example for others. This episode is a must-listen for anyone seeking to deepen their understanding of perseverance, purpose, and the power of a committed mind. Eli’s journey is both inspiring and humbling, providing a roadmap for pushing beyond self-imposed boundaries. Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://calendly.com/andrespreschel/intro-call-with-andresLinks Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode:Experience in conflict. [00:06:09]Humility in warrior mindset. [00:12:51]Intrinsic motivation in training. [00:17:27]Neuroplasticity through challenging experiences. [00:24:24]Embracing the pain cave. [00:30:08]Collective joy through physical activity. [00:39:44]The benefits of pushing limits. [00:46:11]Breath work and athletic performance. [00:52:10]Running for a greater purpose. [01:02:05]Race strategy and aid stations. [01:08:47]Finding purpose in suffering. [01:13:39]The importance of breathing. [01:19:04]Leadership accountability and credit. [01:22:45]Mission for the hostages. [01:25:04] PeopleEli WiningerInstagramDavid GogginsInstagramDr. Kelly McGonigalLinkedIn Peter Attia, MDOfficial WebsitePlacesBring Them Home Now FoundationOfficial WebsiteIDF Special Forces - Sayeret EgozWikipedia: Sayeret EgozLeadville Race SeriesOfficial Website: Leadville Race SeriesBooks and ReferencesHow to Make Stress Your FriendTED TalkNeuroplasticityInformative Article: Neuroplasticity - NIHWHOOPOfficial Website: WHOOPRed Light TherapyYouTube VideoSupport the show

In this insightful episode, I sit down with Alexandra Sheth, a Master of Public Health in Dietetics and Nutritional Sciences and an expert in nervous system regulation. With a background in neuroscience and a passion for blending Western science with Eastern practices, Alexandra has carved a unique path in health and wellness. Her approach merges the tangible with the intangible, creating a holistic framework that embraces both the measurable aspects of health and the deeper, more subtle dimensions of our inner worlds.Our conversation explores Alexandra's transformative journey from conventional medicine to a holistic approach that emphasizes the synergy between mind, body, and energy. We delve into her experiences with somatic breathwork, acupuncture, and functional nutrition, uncovering how these practices can dissolve internal stagnation and restore balance. Whether you’re seeking to deepen your connection to your body, cultivate resilience, or integrate holistic practices into your daily life, Alexandra’s journey and expertise provide a compelling roadmap to living with purpose and intention. Tune in and discover how aligning with the rhythm of life’s seasons can lead to lasting health and fulfillment.Key Points From This Episode:East meets West healing approach. [00:06:14]Muscle testing and holistic health. [00:13:53]Breathing as effective therapy. [00:19:18]Responsibility for modern detachment. [00:28:48]Brain vs. Mind distinction. [00:38:35]Interoception and wearable devices. [00:45:10]Movement, mindfulness, and meals. [00:52:19]Trauma's effect on the body. [01:02:09]Community as a source of strength. [01:09:35]Costa Rica retreat adventure. [01:11:26] Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://calendly.com/andrespreschel/intro-call-with-andresLinks Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumPeopleAlexandra ShethInstagram ProfileWebsite: Sheth StudiosGabor MatéOfficial WebsitePlacesHanu HealthInstagram ProfileModern OmOfficial WebsiteSupport the show

In this special episode, I switch roles and step into the guest seat, giving you a behind-the-scenes look into my own journey—from biohacker and performance coach to someone deeply passionate about living life with intention. I share the experiences that have shaped my philosophy, from my love of spearfishing and being in nature to blending science with real-world application to help others unlock their full potential.I also talk about the power of key performance indicators like HRV and VO2 max, and how they’ve transformed not only my life but the lives of my clients. This conversation touches on the importance of balancing data with intuition, the lessons I’ve learned through coaching, and the way I strive to integrate nature, science, and human connection.If you’re interested in how to elevate your health and performance, or simply curious about the personal side of my journey, this episode is for you. I share insights from my own life, the science I live by, and the small but meaningful changes anyone can make to live a healthier, more intentional life. Join me as I open up about the philosophy that drives me—both on and off the mic.Key Points From This Episode:Intense focus and interests. [00:05:29] Passion or discipline? [00:09:49] Importance of in-person connections. [00:14:09] Positive reframing of failures. [00:24:35] Shedding light on oneself. [00:32:11] Key Performance Indicators in Health. [00:35:15] Expectations and happiness equation. [00:44:32] Podcasting as a connection tool. [00:55:07] In-person connections and rapport. [01:02:03] Breathwork and personal experiences. [01:10:42] Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://calendly.com/andrespreschel/intro-call-with-andresLinks Mentioned in Today’s Episode:Click HERE to save on BiOptimizers MagnesiumPeopleMichael DonovanWebsiteJoe RoganWebsiteSpotify PodcastInstagramDr. Joel KahnOfficial WebsitePeter AttiaOfficial WebsiteBen GreenfieldOfficial WebsiteStacy SimsOfficial WebsiteBooks and References"Atomic Habits" by James ClearAmazon Link"The Almanack of Naval Ravikant" by Eric JorgensonAmazon Link"Die with Zero" by Bill PerkinsAmazon Link"The Body Keeps the Score" by Bessel van der Kolk (mentioned indirectly in context with mental and physical health)Amazon LinkSupport the show