Healio Rheuminations

Adam J. Brown, MD
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Jul 10, 2018 • 19min

Giant Cell Arteritis with Leonard Calabrese, DO

Leonard Calabrese, DO, details the clinical manifestations of giant cell arteritis, the complex scenarios rheumatologists face when working with GCA, and the pathogenesis of this disease. Calabrese also shares clinical pearls and tips for success.    Introduction of Leonard Calabrese, DO :12 Goals of this episode :31 The disease that rheumatologists love 1:02 History of giant cell arteritis 1:51 Gene Hunder, MD, defines large vessel involvement in late ‘80s, ‘90s 4:18 Epidemiology of giant cell arteritis 4:32 Manifestations in detail 5:13 Cranial arteritis 5:20 Jaw claudication 6:04 Ocular involvement 6:44 Signs and symptoms 7:03 The most important thing about ocular ischemia in GCA 9:01 Stroke: A major complication of cranial ischemic GCA 9:25 PMR and/or systemic inflammatory presentations 11:33 A more recent presentation: inflammatory disease of unknown origin 12:19 Large vessel presentations 13:12 Diagnosis of GCA is based on clinical suspicion 14:00 Ophthalmologists must have hypervigilance 14:22 It’s a team sport to attack this disease 14:58 Overview of clinical manifestations 15:08 Histopathology 16:10 How the biopsy should be done 16:38 What about healed arteritis? 17:18 What about arteritis of the vasa vasorum? 17:41 Episode recap 17:54 The most important thing to know 18:17 Leonard Calabrese, DO, is head of Cleveland Clinic’s Section of Clinical Immunology, co-director of Center for Vasculitis Care and Research, and chief medical editor of Healio Rheumatology. We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com.
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Jul 10, 2018 • 17min

A Neck of Deception

What do a fever, stiff neck and leukocytosis have in common with a large swollen knee? Listen to this medical mystery to see if you can figure out the diagnosis, then stick around to hear interesting information you may not know about the disease, including historical perspectives.   Intro :10 A 71-year-old man presents with unilateral knee swelling, fever and neck stiffness :37 Medication overview 2:12 Physical exam findings 2:24 Laboratory findings 3:03 Imaging results 3:33 Rheumatology consult 4:30 Now what? 5:08 CT scan is ordered 6:04 The meningitis mimicker 6:24 History of pseudo-gout 6:54 What do we know about chondrocalcinosis? 7:53 History of Crowned Dens syndrome 9:37 Cervical spine anatomy review 11:05 Data from a single center 12:40 Can this be dangerous? 13:40 Are we sure this is pseudo-gout? 14:20 The role of the CT in the diagnosis of this case 14:50 Treatment options 15:44 “Why not treat the patient with steroids from the start?” 16:12 Email me with questions, or if you know any cases of hydroxyapatite-induced Crowned Dens 16:39 We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. References: Ali S, et al. J Radiol Case Rep. 2011;doi:10.3941/jrcr.v5i8.802. Bouvet JP, et al. Arthritis Rheumatism. 1985;28:1417-20. Ciricillo SF, Weinstein PR. J Neurosurg. 1989;71:141-143. Goto S, et al. J Bone Joint Surg Am. 2007;89:2732-2736. Marson P, Pasero G. Reumatismo. 2012; 63: 199-206. Salaffi F, et al. Clin Exp Rheumatol. 2008;26:1040-1046.

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