This episode covers a rare but life-threatening complication of lupus nephritis called complement-mediated thrombotic microangiopathy. Rheumatologist Lisa Zickuhr, MD, helps us better understand this often-overwhelming topic with a clinical case example, treatment options and practice pearls.
- Intro :10
- Introduction of Lisa Zickuhr, MD, rheumatologist :44
- Complement-mediated thrombotic microangiopathy in lupus is an overwhelming topic 1:50
- Definition of TMA 2:15
- What is MAHA? 3:10
- Four classic symptoms associated with TMA syndromes 3:35
- What causes TMA? 3:50
- Complement-mediated TMA 5:35
- How this is seen in clinical practice 9:10
- Case example of complement-mediated TMA 10:10
- Summary of case presentation 13:05
- What’s next? 13:50
- Takeaways from this clinical presentation 15:48
- Primary and secondary complement-mediated TMA 18:23
- An argument for a primary etiology of complement-mediated TMA in lupus 18:51
- CliffsNotes version for rheumatologists, HCPs caring for lupus patients 21:12
- Therapy for complement-mediated TMA is two-pronged 22:35
- Patient profile 24:05
- Summary 25:10
- Thank you to Dr. Lisa Zickuhr 26:13
Lisa Zickuhr, MD, is a rheumatologist at Washington University in St. Louis.
We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com.
References:
Dragon-Durey MA, et al. J Am Soc Nephrol. 2005:555-563.
Dragon-Durey MA, et al. Semin Thromb Hemost. 2010:633-640.
George JN, et al. N Engl J Med. 2014 Aug 14;371:654-666.
Jönsen A, et al. Arthritis Res Ther. 2011;13:R206.
Laszlo MH, et al. Ann Intern Med. 1955;42:1308-1320.
Nesher G, et al. Semin Arthritis Rheum. 1994;24:165-72.
Zickuhr L, et al. Arthritis Care Res (Hoboken). 2018;doi: 10.1002/acr.23561.