Mind & Matter

Nick Jikomes
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Nov 26, 2024 • 1h 40min

Mental Illness & Substance Abuse: Genetics, Psychosis, THC, Dopamine & the Brain | Jibran Khokhar | 190

Jibran Khokhar, an Associate Professor at Western University, shares insights on the neurobiology of mental illness and substance use disorders. He discusses the complex relationship between THC and psychosis, emphasizing how cannabis affects dopamine in the brain. The conversation also dives into the comorbidity of schizophrenia and substance use, the variances in THC metabolism based on sex, and the differences between vaping and smoking nicotine. Throughout, genetic influences and the challenges in addiction research are notably highlighted.
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Nov 21, 2024 • 33min

Vaccine Contamination & Fiat Science | Kevin McKernan | 196

Send us a textFull episodes are available to paid subscribers on the M&M Substack and free on YouTube. This is a free, partial version.About the guest: Kevin McKernan is the founder and Chief Science Officer of Medicinal Genomics. He has worked in biotechnology since the early 1990s, when he was involved in the Human Genome Project.Episode summary: Nick and Kevin discuss: components of the COVID vaccines, including modified mRNA & lipid nanoparticles; DNA contamination in COVID vaccines; vaccine adverse events & IgG4 immune modulation; concerns with COVID PCR testing; origins of the SARS-CoV-2 virus; Fiat Science from the AIDS epidemic to today; how Big Pharma works with government regulators; decentralized medicine; and more.Related episodes:M&M #149: DNA & RNA Biology, mRNA Vaccines, Vax Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernan*This content is never meant to serve as medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts
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Nov 18, 2024 • 1h 3min

Skin Biology: Hormones, Light, Vitamin D, Melatonin & Stress | Andrzej Slominski | 189

Send us a textAbout the guest: Andrzej Slominski, MD, PhD is a dermapathologist and skin biologist who has spent decades studying skin biology, especially regarding endocrinology (hormones), stress response, photobiology, and more.Episode summary: Nick and Dr. Slominski discuss: hormone production in the skin; vitamin D photobiology; risks and benefits of UVB light; skin cancer & sunscreen; protective effects of melatonin production in the skin; and more.Related episodes:M&M #104: Benefits & Risks of UV Radiation & Sunlight, Skin Health, Vitamin D, Nitric Oxide, Evolution of Skin Color | Richard Weller*This content is never meant to serve as medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts
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Nov 13, 2024 • 1h 12min

Psychedelics, Functional Neuroimaging & the Human Brain | Joshua Siegel | 188

Joshua Siegel, a psychiatrist and systems neuroscientist at NYU, explores the fascinating realm of psychedelics and their impact on the brain. He discusses how fMRI technology unveils the intricate relationship between neural activity and blood flow. Siegel delves into the role of the serotonin 2A receptor and its significance in understanding psychedelics. The conversation also highlights the challenges of subjective experiences in clinical trials, revealing how individual expectations can shape treatment outcomes.
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Nov 10, 2024 • 1h 9min

Synesthesia & Effects of Digital Technology on Brain & Mental Health | Richard Cytowic | 187

Send us a textAbout the guest: Richard Cytowic is a neurologist, poplar science writer and professor at the George Washington University. Episode summary: Nick and Dr. Cytowic discuss: the effects of smart phones and social media on the developing and adult brain; artificial blue light vs. broad spectrum natural light; attention & addiction to technology; sensory overstimulation & “virtual autism”; synesthesia and multimodal sensory perception; and more.Related episodes:M&M 78: Nature vs. Nurture, Neurogenetics, Personality, Autism, Schizophrenia, Synesthesia, Perception, Agency & Free Will | Kevin Mitchell*This content is never meant to serve as medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts
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Nov 6, 2024 • 1h 9min

Kidney Biology: Simple Diet & Lifestyle Practices for Kidney Health | Thomas Weimbs | 186

Send us a textAbout the guest: Thomas Weimbs, PhD is a biologist at UC-Santa Barbara whose lab studies kidney function in health and disease.Episode summary: Nick and Dr. Weimbs discuss: basic kidney biology; kidney stones and their causes, including dietary oxalates and fructose; the kidney damaging effects of common pharmaceuticals like Ibuprofen; the beneficial effects of BHB and ketosis for kidney health; the myth that high protein intake is bad for the kidney; kidney diseases and their causes; and more.Full version available on Substack and YouTube.Related episodes:M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'AgostinoM&M #139: Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease | Mark Mattson*This content is never meant to serve as medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts
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Oct 31, 2024 • 43min

Self-Experimentation (n=1) in Metabolic Health, Lipid-Energy, Trust in Medical Institutions | Nick Norwitz | 195

Send us a textFull version available on Substack and YouTube.About the guest: Nick Norwitz, PhD received his PhD in Physiology at Oxford University and is finishing his MD degree at Harvard Medical School. He is also an independent content creator focused on making metabolic health mainstream.Episode summary: Nick and Dr. Norwitz discuss: blood lipids & cholesterol; high cholesterol levels and what they can mean for different people; the “lean mass hyper-responder” phenotype to carb restriction; ketogenic & carnivore diets; public trust in medical & science institutions; n=1 (“n of one”) science experiments; and more.Related episodes:M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino*This content is never meant to serve as medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts
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Oct 30, 2024 • 1h 4min

Sugar & Sweeteners: Are They Really Addictive or Unhealthy? | Nicole Avena | 185

Send us a textFull version available on Substack and YouTube.About the guest: Nicole Avena, PhD is a neuroscientist at Mount Sinai. She studies the effects of sugar and diet on animal behavior and the brain. She is also the author of, “Sugarless.”Episode summary: Nick and Dr. Avena discuss: drug addiction vs. food addiction; glucose, fructose & artificial sweeteners; the extent to which sugar consumption can drive dependency & withdrawal; fructose metabolism & live health; sweetness & palatability; ultra-processed foods; and more.Related episodes:M&M 140: Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig*This content is never meant to serve as medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts
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Oct 27, 2024 • 1h 7min

Endocrine Disruptors & Metabolism: Microplastics, BPA, Estrogen, Insulin, Pancreas & Metabolic Dysfunction | Angel Nadal | 184

Angel Nadal, a Spanish biologist specializing in endocrine disruptors and pancreatic functions, discusses the intricate relationship between microplastics, BPA, and hormone signaling. He dives into how these disruptors impact insulin signaling and metabolic health, emphasizing their effects on both males and females. The conversation touches on the critical role of estrogen in metabolism and how BPA can influence developmental outcomes during pregnancy. Nadal also highlights sex differences in responses to endocrine disruptors, offering insights into gender-specific health implications.
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Oct 23, 2024 • 59min

Calorie Restriction & Fasting: Aging, Immunity, Health Biomarkers, Stress, Genetics | Gary Churchill | 183

Send us a textAbout the guest: Gary Churchill, PhD is a statistician & geneticist at the Jackson Research laboratory in Maine. His lab uses a systems approach to investigate the genetics of complex biological traits in health & disease.Episode summary: Nick and Dr. Churchill discuss: his recent papers looking at the effects of caloric restriction & intermittent fasting on nearly 1,000 genetically diverse mice; how dietary restrictions affect longevity, metabolic health, immunity, and hundreds of biomarkers; the role of genetics vs. diet in aging; and more.Related episodes:M&M #139: Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease*This content is never meant to serve as medical advice.*Full episode available free on Substack & YouTube.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

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