

MeSsy with Christina Applegate & Jamie Lynn Sigler
Wishbone Production
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
Episodes
Mentioned books

Sep 9, 2025 • 56min
We Are Not the Things That Happen to Us
This week, Christina and Jamie read listener emails and discuss conditional friends, not identifying as the things that happen to us, staying honest, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout.
Everyplate - Dig into these flavor-packed meals your household will love. New customers can enjoy this special offer of only $1.99 a meal. Go to everyplate.com/podcast and use code MESSY199 to get started
O-Positiv - Take proactive care of your health and head to OPositiv.com/MESSY or enter MESSY at checkout for 25% off your first purchase.
Magic Spoon - Get 5 dollars off your next order at MagicSpoon.com/MESSY. Or look for Magic Spoon on Amazon or in your nearest grocery store.

Sep 2, 2025 • 1h 10min
Change Your Brain, Change Your Pain with Dr. Daniel Amen
This week, Christina and Jamie are joined by Dr. Daniel Amen, a physician, double board-certified psychiatrist, and award-winning researcher. They discuss why pain can also live in your brain, the doom loop and how to get out of it, the cost of repressed emotions, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Hexclad - Find your forever cookware @hexclad and get 10% off at hexclad.com/messy #hexcladpartnerHoneylove:
Save 20% Off Honeylove by going to honeylove.com/messy #honeylovepod
AGZ - Start taking your sleep seriously with AGZ. Head to drinkag1.com/messy to get a FREE welcome kit with the flavor of your choice that includes a 30 day supply of AGZ and a free frother
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/messy. This is an amazing value.

Aug 26, 2025 • 1h 2min
We Have to Pivot
This week, Christina and Jamie read listener emails and discuss their kids starting the new school year, the power of manifestation, accepting reality, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/messy. This is an amazing value.
O-Positiv - Take proactive care of your health and head to OPositiv.com/MESSY or enter MESSY at checkout for 25% off your first purchase.
Sleep Number - It’s the Sleep Number's Biggest Sale of the Year. 25% Off the i8 Bed plus free home delivery. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.
Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout. Experience the world’s #1 blanket with Lola Blankets.

Aug 19, 2025 • 59min
I Just Wanna Be Stoned
This week, Christina and Jamie read listener emails and discuss hormones, housewives, acknowledging the struggle, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Sleep Number - It’s the Sleep Number's Biggest Sale of the Year. 25% Off the i8 Bed plus free home delivery. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.
MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at mudwtr.com/messy! #mudwtrpod
iRestore - Unlock your best hair & skin with @iRestorelaser and HUGE savings on the iRESTORE Elite + Illumina Face Mask Bundle with code Messy25 at irestore.com/messy25#irestorepod
ZocDoc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today.
Everyplate - Dig into these flavor-packed meals your household will love. New customers can enjoy this special offer of only $1.99 a meal. Go to everyplate.com/podcast and use code MESSY199 to get started. Applied as discount on first box, limited time only.

Aug 12, 2025 • 1h 28min
Ed Helms
This week, Christina and Jamie are joined by Ed Helms. They discuss working together on "Vacation," his love of comedy, the importance of curiosity, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout. Experience the world’s #1 blanket with Lola Blankets.
Magic Spoon - Get 5 dollars off your next order at MagicSpoon.com/MESSY. Or look for Magic Spoon on Amazon or in your nearest grocery store.
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout.Sleep Number - It’s the Sleep Number's Biggest Sale of the Year. 25% Off the i8 Bed plus free home delivery. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/messy.

Aug 5, 2025 • 1h 10min
Live From the Hospital
This week, Christina joins Jamie live from the hospital in LA. They discuss what Christina’s going through, her recent trip abroad, their upcoming memoirs, the way the universe works, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
IRestore - Unlock your best hair & skin with @iRestorelaser and HUGE savings on the iRESTORE Elite + Illumina Face Mask Bundle with code MESSY25 at irestore.com/messy25 #irestorepod
O-Positiv - Take proactive care of your health and head to OPositiv.com/MESSY or enter MESSY at checkout for 25% off your first purchase.
GoPure - Get 25% Off @goPure with code Messy at https://www.gopurebeauty.com/messy #goPurepod
Honeylove - Save 20% Off Honeylove by going to honeylove.com/messy #honeylovepod
Sleep Number- It’s the Sleep Number's Biggest Sale of the Year. 25% Off the i8 Bed plus free home delivery. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.

Jul 29, 2025 • 1h 11min
Jenny Mollen
This week, Christina and Jamie are joined by Jenny Mollen, a New York Times bestselling author and actor. They discuss the feeling of not being in control, the trials of parenting, and more.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Honeylove - Save 20% Off Honeylove by going to honeylove.com/messy #honeylovepodMudwtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code Messy at mudwtr.com/messy! #mudwtrpodEveryplate - Dig into these flavor-packed meals your household will love. New customers can enjoy this special offer of only $1.99 a meal. Go to everyplate.com/podcast and use code Messy199 to get started. Applied as discount on first box, limited time only.

Jul 22, 2025 • 1h 4min
Easy on My Nervous System
This week, Christina and Jamie read listener emails and discuss wins and losses, shows that are easy on the nervous system, why people don't understand invisible diseases, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
O-Positiv - Take proactive care of your health and head to OPositiv.com/MESSY or enter MESSY at checkout for 25% off your first purchase.
Everyplate - Dig into these flavor-packed meals your household will love. New customers can enjoy this special offer of only $1.99 a meal. Go to everyplate.com/podcast and use code Messy199 to get started. Applied as discount on first box, limited time only.
Function - Function currently has a waitlist, but they are offering my audience the chance to skip it! Head to functionhealth.com/MESSY or enter code MESSY when signing up to skip the waitlist!

Jul 15, 2025 • 1h 12min
Any Movement Counts with Doctor Gretchen
This week, Christina and Jamie are joined by Dr. Gretchen Hawley, an MS-certified specialist and physical therapist. They discuss what to do if you're feeling overwhelmed, the importance of staying consistent, why mindset is just as important as movement, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Get the latest research from Doctor Gretchen here:
https://www.doctorgretchenhawley.com/offers/MTbWv7kN?coupon_code=MESSY30
This episode is sponsored by:
Mudwtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code Messy at mudwtr.com/messy! #mudwtrpod
Beam is offering UP TO 40% off their best-selling Dream Powder for our
listeners. Go to shopbeam.com/MESSY and use code MESSY at checkout.
Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. Beam

Jul 8, 2025 • 60min
Life Is Like an Episode of Chopped
This week, Christina and Jamie read listener emails and discuss body work, Christina’s new obsession, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout.
Mudwtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code Messy at mudwtr.com/messy! #mudwtrpod HoneyLove - Save 20% Off Honeylove by going to honeylove.com/messy ! #honeylovepod