
MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
Latest episodes

Jun 10, 2025 • 1h 1min
How Could You Not Like Pizza?
This week, Christina and Jamie read listener emails and discuss New York pizza, the trick to finding lost jewelry, how brain inflammation affects us, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout.
Honeylove- Save 20% Off Honeylove by going to honeylove.com/messy #honeylovepod
OPositiv - Take proactive care of your health and head to OPositiv.com/MESSY or enter MESSY at checkout for 25% off your first purchase.
Function - Function currently has a waitlist, but they are offering my audience the chance to skip it! Head to functionhealth.com/MESSY or enter code MESSY when signing up to skip the waitlist!”
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/MESSY. This is an amazing value and you get unlimited access to Calm’s entire library

Jun 3, 2025 • 1h 3min
Kaitlyn Bristowe
This week, Christina and Jamie are joined by Kaitlyn Bristowe. They discuss starting over, the impact of therapy, their love of dance, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
BetterHelp - This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.
Magic Spoon - Get 5 dollars off your next order at MagicSpoon.com/MESSY. Or look for Magic Spoon on Amazon or in your nearest grocery store.
Go Pure - Get 25% OFF @goPure with code MESSY at https://gopurebeauty.com/MESSY! #goPurepod

May 27, 2025 • 1h 3min
F Our Lives... Let’s Read Some Emails
This week, Christina and Jamie read listener emails and discuss being the “everything” friend, feeling validated in what you’re going through, finding support, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Shop MeSsy merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/home
This episode is sponsored by:
BetterHelp - This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.”
Beam - Visit https://shopbeam.com/MESSY and use code MESSY to get our exclusive discount of up to 40% off.
Sleep Number - It's the Sleep Number everything smart bed sale. Every smart bed and base are on sale during our Memorial Day event. Up to 50% off. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.
MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at mudwtr.com/messy ! #mudwtrpod
iRestore - Unlock your best skin with @iRestorelaser and HUGE savings on the iRestore Illumina Face Mask with code MESSY25 at irestore.com/messy25! #irestorepod

May 20, 2025 • 1h 12min
David Faustino
This week, Christina and Jamie are joined by Christina’s TV brother, David Faustino. They share their memories from “Married... with Children,” and discuss the grief of losing a parent, choosing to live a sober life, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Shop MeSsy Merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/home
This episode is sponsored by:
Magic Spoon - Get 5 dollars off your next order at MagicSpoon.com/MESSY. Or look for Magic Spoon on Amazon or in your nearest grocery store.
Function - In the spirit of Long Live and taking control of your health, get a $100 credit towards your annual membership at: www.functionhealth.com/MESSY This $100 credit is only for the first thousand listeners.
Sleep Number - It's the Sleep Number everything smart bed sale. Every smart bed and base are on sale during our Memorial Day event. Up to 50% off. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/MESSY. This is an amazing value and you get unlimited access to Calm’s entire library

May 13, 2025 • 1h 26min
Conan O'Brien
This week, Christina and Jamie are joined by Conan O'Brien. They discuss perspective, the importance of having morals, the circle of life, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Shop MeSsy merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/home
This episode is sponsored by:
BetterHelp - “This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.”
Sleep Number - It's the Sleep Number everything smart bed sale. Every smart bed and base are on sale during our Memorial Day event. Up to 50% off. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.
Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today.
GoPureGet 25% OFF @goPure with code MESSY at https://gopurebeauty.com/MESSY! #goPurepod
Beekeeper's Naturals - Beekeeper’s Naturals is offering you an exclusive offer: Go to beekeepersnaturals.com/MESSY or enter code MESSY to get 20% off your order

4 snips
May 6, 2025 • 1h 7min
Let the Mess Out
This week, Christina and Jamie read listener emails and discuss “Bad Moms,” princess cake, EMDR therapy, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Shop MeSsy march: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/home
This episode is sponsored by:
BetterHelp - “This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.”
Fatty15 - Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/MESSY and using code MESSY at checkout.
Function - We recommend Function. Learn more and join using my link. The first 1000 get a $100 credit toward their membership. Visit www.functionhealth.com/MESSY to own your health.
Sleep Number - It's the Sleep Number everything smart bed sale. Every smart bed and base are on sale during our Memorial Day event. Up to 50% off. Limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.

Apr 29, 2025 • 1h 7min
JoAnna Garcia Swisher
This week, Christina and Jamie are joined by JoAnna Garcia Swisher, who is an actress, the co-founder of The Happy Place, and one of Jamie’s best friends. They discuss navigating grief, losing a parent, the power of authenticity, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Shop MeSsy merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/home
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/MESSY
AG1- AG1 is offering new subscribers a FREE $76 gift when you sign up. You’ll get a Welcome Kit, a bottle of D3K2 AND 5 free travel packs in your first box. So make sure to check out DrinkAG1.com/messy to get this offer!
Sleep Number - The only bed that lets you make each side firmer or softer whenever you like – your Sleep Number setting. Sleep Number Beds Start at $999. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.

Apr 22, 2025 • 1h 1min
Everybody Walks Too Fast
This week, Christina and Jamie read listener emails and discuss the feeling of cleaning your closet, the difference between healing and fixing, doing the best you can, and more.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischShop MeSsy march: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/homeThis episode is sponsored by:MixTiles - Get 35% off on all orders above $139 @MixTiles with code MESSY at https://www.mixtiles.com/MESSY ! #mixtilespodFunction - Function currently has a waitlist, but they are offering my audience the chance to skip it! Head to functionhealth.com/MESSY or enter code MESSY when signing up to skip the waitlist!” Sleep Number - For a limited time, Sleep Number smart beds start at $849. Prices higher in AK and HI. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.iRestore -Unlock your best skin with @iRestorelaser and HUGE savings on the iRestore Illumina Face Mask with code MESSY25 at irestore.com/messy25 #irestorepod

Apr 15, 2025 • 1h 14min
Diana-Maria Riva
This week, Christina and Jamie are joined by Diana-Maria Riva, who was Christina’s co-star on “Dead to Me.” They discuss their experience working together, how to sustain a career, finding your voice, her work with Latina’s Acting Up, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Branch Basics - Get 15% off Branch Basics with the code Messy at https://branchbasics.com/messy #branchbasicspodSleep Number - For a limited time, Sleep Number smart beds start at $849. Prices higher in AK and HI. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.AG1 - AG1 is offering new subscribers a FREE $76 gift when you sign up. You’ll get a Welcome Kit, a bottle of D3K2 AND 5 free travel packs in your first box. So make sure to check out DrinkAG1.com/messy to get this offer! Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc dot com slash MESSY to find and instantly book a top-rated doctor today. Calm - Stress less, sleep more, and live better with Calm. For listeners of our show, Calm is offering an exclusive offer of 40% off a Calm Premium Subscription at calm.com/MESSY

Apr 8, 2025 • 59min
You Don’t Have to Be Perfect at Life
This week, Christina and Jamie read listener emails and discuss how to open up about your diagnosis, the stress of trying to be perfect, finding balance, and more.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischJoin our discord channel: https://discord.com/invite/3SPT9c7AtcThis episode is sponsored by:Fatty15 - Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/MESSY and using code MESSY at checkout.Function - Function currently has a waitlist, but they are offering my audience the chance to skip it! Head to functionhealth.com/MESSY or enter code MESSY when signing up to skip the waitlist!” OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/ #oneskinpodGoPure - Get 25% Off @goPure with code MESSY at https://www.gopurebeauty.com/messy #goPurepod