Floyd Romesberg added two letters to DNA's ancient four-letter alphabet. He got this running in cells. And coding proteins. His cell lines have passed it down hundreds of generations. Now what?

Stewart Brand, influential over six decades, discusses de-extinction, the Whole Earth Catalog, internet evolution, and genetic rescue efforts. Topics include visionary tech demos, the Long Now Foundation's 10,000-year clock, and climate change solutions like solar geoengineering.

An examination of the science of psychopathy from my buddy Jordan Harbinger’s terrific podcast. This bonus episode is in addition to the two new original episodes I’m creating this month.

Key aspects of medical technology are improving even faster than computers. What are the ramifications for our health? For our lifespans? Dr. Daniel Kraft has tremendous insights into all of this - particularly as it relates to cancer.

The largest-ever clinical trial of a psychedelic drug will soon begin in Europe and North America. The drug is psilocybin - the active ingredient in magic mushrooms. The target is treatment-resistant depression.

Quantitative Psychologist Don Hoffman has a head-spinning take on the true nature of reality vs. what our senses report to us. Is it the most counterintuitive insight since Pythagoras figured the Earth is round?

In this very atypical episode, the tables turn and I'm the interviewee! We discuss all of my creative projects, including this podcast series. Recorded live at The Battery in San Francisco.

George Church helped found 22 companies, and co-invented the paradigm-shattering gene editing technique CRISPR. In our interview, he delivers a sweeping survey of the world of synthetic biology, and makes some astounding predictions

Rodney Brooks is a founding luminary of TWO vital domains in tech: robotics and AI. He's the father of the Roomba, the long-time head of MIT's AI lab, and a serial entrepreneur. Few can rival his breadth & depth in technology.

Neuroscientist David Eagleman has done groundbreaking work on how we perceive time. Now he hopes to radically expand the pantheon of human senses.