

Hypertrophy Past and Present
Chris Beardsley and Jake Doleschal
A deep dive into the science of muscle growth. Hosted by Chris Beardsley and Jake Doleschal, this podcast explores hypertrophy training through the lens of pre-steroid era bodybuilding and modern muscle physiology.
Episodes
Mentioned books

Jan 19, 2026 • 1h 31min
035 Which advanced methods work? Cluster sets, drop sets, pre-fatigue, and more!
Jake and Chris examine advanced training techniques like cluster sets, drop sets, and pre-fatique strategies. They critique classic methods, revealing why supersets often reduce stimulus instead of enhancing it. Discover how the physiological drop set could maximize recruitment while managing fatigue. The duo highlights the intricacies of agnostic versus antagonist supersets, and the efficiency gains from giant sets. Tune in for insights into effective training strategies and practical tips for optimizing your workout routine.

15 snips
Jan 11, 2026 • 1h 29min
034 Voluntary activation deficit: exercise selection, muscle mass, and form
Jake and Chris dive into Larry Scott's Golden Era training plan, revealing insights into the evolution of hypertrophy programming. They explore the impact of anabolic drugs on exercise selection and discuss misconceptions around exercise redundancy. The concept of voluntary activation deficit is introduced, shedding light on how muscle recruitment works. They delve into why excessive focus on form can hinder growth and emphasize the importance of exercise variety. The conversation also addresses practical exercise selection for beginners.

5 snips
Jan 4, 2026 • 1h 6min
033 How to write programs that satisfy client expectations AND really work
This discussion dives into common pitfalls coaches face when creating training programs. They explore Bob Hoffman’s minimalist full-body routine, highlighting its strengths and weaknesses. Key strategies are shared for balancing client expectations for novelty with the need for consistency in programming. Tips include using exercise swaps, effective rest periods, and managing time to improve training outcomes. The duo emphasizes the importance of perceived variety through smart structuring, setting clients up with manageable, effective sessions.

16 snips
Dec 28, 2025 • 1h 31min
032 Common training mistakes to avoid in 2026
The hosts dive into common gym mistakes that derail progress, spotlighting George Eiferman's 1952 full-body routine. They highlight issues like unnecessary instability, cardio-focused sets that compromise hypertrophy, and the hazards of excessive muscle damage. Frequent exercise changes are critiqued for stunting gains, while tracking progress is emphasized as essential. Curious about warm-ups? They debunk myths and discuss proper techniques. Tune in for smarter strategies to kickstart your training journey!

23 snips
Dec 22, 2025 • 1h 17min
031 How steroids and TRT increase injury risk (and how modifying your training might help)
Dive deep into Mike Mentzer’s intriguing training methods, exploring how his two-way split might be more physiology-friendly than expected. Discover the hidden dangers of anabolic steroid use, including how it affects tendon structure and increases injury risk. The discussion shifts to modern training trends like higher reps and shorter rest periods in response to these risks. Practical tips on injury management, like using blood flow restriction techniques and machine workouts, highlight ways to stay safe while pursuing gains.

10 snips
Dec 14, 2025 • 1h 36min
030 Everyone's wrong about muscle activation + how to compare hypertrophy programs (WNS)
Dive into the intriguing world of bodybuilding as two hosts analyze Ken Waller's iconic 1975 training split and its evolution during the anabolic era. They discuss how high-volume workouts can be deceptively recoverable and explore the intricacies of muscle activation deficits. The Weekly Net Stimulus model is introduced, highlighting its limitations and practical applications for hypertrophy training. Listeners will learn why targeting specific muscle fibers is crucial and how variety in exercise impacts development for athletes.

13 snips
Dec 7, 2025 • 1h 19min
029 Elevated MPS ≠ muscle growth
Dive into the legacy of John Grimek, where his full-body gaining routine reveals the practicality of Silver Era training. Explore the concept of muscle protein synthesis (MPS) and its relationship to muscle growth, debunking misleading assumptions. Discover why elevated MPS doesn’t guarantee hypertrophy, especially in various scenarios like injuries and aerobic exercise. Learn how external factors like diet and stress impact muscle breakdown, shaping insights for natural athletes managing their training and recovery.

21 snips
Nov 30, 2025 • 1h 28min
028 How does dieting affect hypertrophy?
Dive into the history of dieting with reflections on Clancy Ross' 1945 muscle-building routine, which surprisingly outshines many modern fat-loss plans. Discover how caloric restrictions impact muscle protein synthesis and breakdown while highlighting effective training strategies. Learn how pre-workout carbs and adjusting training volume can help preserve muscle during dieting. Delve into the role of stress in dieting and get practical tips for personalized and less stressful diet approaches to achieve your fitness goals.

10 snips
Nov 23, 2025 • 1h 13min
027 Are 4 reps optimal?! New study: stimulating reps vs volume load
Dive into the contrasting training philosophies of Bill Pearl from 1967, highlighting his high-volume six-day split that paved the way for modern routines. Discover how anabolic steroids transformed recovery and training volume, breaking traditional feedback loops. A new study uncovers that both heavy and light loads yield similar hypertrophy, challenging the volume load hypothesis. Join the discussion on practical programming for beginners versus advanced lifters and the real-world challenges of implementing these findings.

9 snips
Nov 16, 2025 • 1h 20min
026 How does insufficient sleep affect hypertrophy / atrophy?
Explore the intriguing world of Bill Pearl's 1957 full-body routine and its connection to the evolution of bodybuilding. Discover how insufficient sleep can trigger muscle atrophy through stress responses and the role of glucocorticoids. Learn why natural lifters face significant muscle loss when dieting while sleep-deprived, unlike enhanced athletes. Gain practical tips on adjusting training strategies during periods of poor sleep and understand the importance of tackling sleep issues before dieting. A fascinating mix of science and practical advice awaits!


