ReInvent Healthcare

Dr. Ritamarie Loscalzo
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Aug 2, 2023 • 19min

Decoding Detoxification Through Genetic SNPs And Lab Testing

This week on ReInvent Healthcare, I emphasize the importance of understanding certain genetic variants and their impact on detoxification pathways. As well as certain tests you can suggest to your clients and foods that can help their detoxification pathways so they live a balanced lifestyle.IN THIS EPISODE:Defining Detoxification PathwaysDetoxification is a critical function, especially in today's world filled with environmental toxins, pesticides, and pollutants. The liver plays a crucial role in detoxification, and there are two phases of detoxification - Phase 1 and Phase 2. Understanding genetic SNPs (single nucleotide polymorphisms) and their role in the body's detox pathways give us valuable insights into individual variations and susceptibilities.Some Detoxification SNPs - There are several genetic SNPs related to detoxification pathways, such as CYP1A1, CYP1A2, CYP1B1, CYP3A4, CYP2C9, and others. These SNPs influence the detoxification of environmental toxins, caffeine, estrogen, prescription drugs, aflatoxin, and more. Understanding these SNPs allows us to identify potential imbalances in detox pathways and helps us make informed decisions for personalized wellness strategies.Importance of TestingTesting is essential to determine whether the detoxification SNPs are active and causing imbalances in the detox pathways. Organic acid tests and blood tests, such as liver function tests and methylation markers, can help identify potential issues. By combining genetic information with lab testing, we gain a comprehensive view of a person's detoxification capabilities. Understanding genetic SNPs and lab results helps us guide patients toward avoiding toxic exposures, environmental pollutants, and food additives that may burden their detox pathways.How To Support DetoxificationOnce genetic SNPs and active detox pathways are identified, our clients can be educated on avoiding toxic substances and making lifestyle changes. These changes may include using non-toxic household products, choosing organic food, avoiding food additives, and reducing exposure to common allergens. Additionally, incorporating certain detox-supporting herbs like artichoke leaf, burdock root, dandelion, and Hawthorn berry can be beneficial.References:Get our FREE Guide to Taking a Detailed Health History that gets you to root causes Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Check out our other episodes about Functional Food Facts here.
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Jul 26, 2023 • 56min

The Importance of a Balanced Microbiome for Optimal Health and Wellness

This week on ReInvent Healthcare, I bring back an episode about a talk I had on Microbiomes with my guest, Steph Jackson. Together we talk about the importance of diversity, butyrate, and using fermentation , and how to balance the microbiome for optimal health. Listen to the full episode to find out more.IN THIS EPISODE:Importance of Short Chain Fatty Acid (SCFA) productionIt is beneficial for clients to improve their short chain fatty acid production, as SCFAs play a crucial role in gut lining integrity, metabolic balance, and sleep schedule regulation. SCFAs like butyrate are essential for overall gut health.Resistant Starch on Gut MicrobiotaIf clients do not consume enough resistant starch, it can lead to a reduction in beneficial bacteria like bifidobacteria and other essential microbes. Resistant starches naturally discourage the opportunistic bacteria and encourage biodiversity in the microbiome. Food preparation and a variety of resistant starches is needed to increase the diversity in the microbiome to improve gut integrity and benefit metabolic health.Diverse Fiber-Rich Diet for Gut HealthTo support the growth of beneficial bacteria like bifidobacteria, clients need to consume a spectrum of fiber-rich foods, including colorful plant foods. Just relying on probiotics or isolated fibers may not be enough to promote a healthy gut microbiome. A varied diet with different types of fiber is essential for overall gut health.References:Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Watch the video version with charts and graphics here.Check out our other episodes about Functional Food Facts here. Biohack your Gut with Steph Jackson’s The Friendly Flora Collective.Listen to my full Part 1 with Steph here.Listen to my full Part 2 with Steph here.
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Jul 19, 2023 • 42min

The Link Between Caffeine Intake and Estrogen Metabolism

This week on ReInvent Healthcare, I bring back a talk I had about caffeine and estrogen. For those who have so many clients who are addicted to caffeine and are unwilling to lessen their caffeine intake, you can show them why it’s important, by explaining this caffeine’s effects on the estrogen metabolism and the inherent risks. Listen to the full episode to find out more.IN THIS EPISODE:Caffeine and Breast CancerCaffeine’s effect on the body revolves around the enzyme CYP1A2 and its implications on breast cancer risk. The enzyme's had a significant role in detoxifying caffeine, accounting for approximately 90-95% of its clearance. Constant caffeine exposure may divert CYP1A2 from its detoxification function in estrogen metabolism to detecting caffeine, resulting in reduced capacity to detoxify and eliminate  toxic estrogen metabolites. This diversion potentially leads to estrogen dominance, which can disrupt hormonal balance and increase the risk of breast and other hormone related cancers.Genetic variations in the CYP1A2 gene influence caffeine and estrogen metabolism. Individuals with specific genetic profiles may exhibit altered caffeine and estrogen metabolism, warranting a personalized approach in managing caffeine consumption and lifestyle choices. For individuals with genetic variations, caffeine should be reduced or eliminated to minimize potential health risks associated with estrogen imbalance and breast cancer.Caffeine’s Effect on EstrogenProlonged caffeine exposure diverts CYP1A2 from its primary role in metabolizing estrogens, potentially leading to estrogen dominance, hormonal imbalances, and related health concerns. The intricate interplay between caffeine and estrogen levels underscores the importance of personalized lifestyle choices, particularly for individuals with specific genetic variations in the CYP1A2 gene.Chronic caffeine consumption is also linked to increased blood sugar levels, insomnia, acid reflux, and alterations in cortisol production, all of which can disrupt estrogen and progesterone balance. Surprisingly, caffeine's potential cross-reactivity with gluten potentially impacts susceptible individuals and further complicates estrogen-related health outcomes. The Gut Microbiome and EstrogenCertain bacteria in the gut are capable of metabolizing estrogen, specifically by producing an enzyme called β-glucuronidase. This enzyme has the ability to break down estrogen conjugates, which are inactive forms of estrogen, into active and bioavailable estrogen.The activity of β-glucuronidase can lead to increased levels of estrogen in the body, as the breakdown of conjugated estrogen allows for its reabsorption into circulation. This can potentially impact hormone balance and contribute to various estrogen-related conditions.References:Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Watch the video version with charts and graphics here.
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Jul 12, 2023 • 26min

Unraveling the Histamine Puzzle with Functional Medicine

This week on ReInvent Healthcare, I tackle Histamines. I explore its underlying causes, symptoms, and how functional medicine offers a holistic approach to address this complex issue. Join me as I navigate the intricate pathways of histamine metabolism and discover evidence-based strategies to restore balance and promote overall well-being. Listen to the full episode to learn more. IN THIS EPISODE:Histamine IntoleranceThis refers to a condition where individuals experience adverse reactions to histamines in the body. Histamine intolerance can manifest as symptoms such as migraines, nasal congestion, hives, insomnia, and difficulty tolerating fermented foods. Histamine intolerance occurs when the body is unable to break down histamine efficiently due to a deficiency in enzymes like diamine oxidase (DAO) and histamine methyltransferase (HMNT).Causes and Factors of Histamine IntoleranceThere are several possibilities for the underlying causes of histamine intolerance.  Genetic variants can affect the body’s capacity for breaking down histamine. Imbalances in gut microbes, leaky gut syndrome, and mast cell activation can contribute to increased histamine production. Chronic exposure to allergens or harmful chemicals can also lead to higher histamine levels in the body.How To Manage HistaminesTaking antihistamines may not be the best solution. Several strategies can help manage histamine intolerance. These strategies include addressing nutrient imbalances, such as ensuring sufficient intake of vitamin B6, vitamin C and quercetin, which support histamine regulation. Certain supplements like DAO can aid in breaking down histamine. It may also be helpful to follow a low-histamine diet, avoiding high-histamine foods like aged cheeses, fermented foods, and leftovers. Additionally, supporting gut health, managing stress, and adopting a healthy lifestyle can contribute to reducing histamine intolerance symptoms.References:Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Purchase Dr. Ben Lynch’s Dirty Genes Histamine workbook here.
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Jun 28, 2023 • 47min

Nurturing Breast Health through Functional Medicine with Dr. Jenn Simmons

In this episode of ReInvent Healthcare, we go in-depth on breast health and how functional medicine can truly make a difference together with my guest, Dr. Jenn Simmons. Dr. Jenn Simmons was Philadelphia's first Fellowship trained breast surgeon. Her own illness led her to discover functional health and how it works wonders for the body, especially breast health. IN THIS EPISODE:Identify Root Causes of Symptoms, Not Suppress By investigating factors such as genetics, environmental influences, lifestyle choices, nutrition, and stress levels, functional health practitioners seek to understand the interconnectedness of various bodily systems. This comprehensive approach seeks the underlying causes, promoting true healing and long-term wellness rather than temporary symptom relief.The Empowerment of EducationEducation empowers individuals by providing them with a deeper understanding of their health, enabling them to actively participate in their healthcare decisions, and encouraging them to take ownership of their well-being. Through education, personalized plans, and collaborative relationships with practitioners, functional health empowers individuals to make informed choices, implement lifestyle modifications, and proactively work towards optimal health and vitality. By shifting the focus from passive patients to active participants, education empowers individuals to take charge of their health and pursue a path of wellness.The Benefits of Fasting and Grain-Free DietWhen it comes to eating clean and healthy, it is good for clients to try a sort of fasting. Some benefits include:1. Fasting and cutting grains can decrease inflammation levels in the body, which is associated with various chronic conditions such as heart disease, arthritis, and certain cancers2. Avoiding grains can promote better digestive health and alleviate conditions such as bloating, gas, and irritable bowel syndrome (IBS) symptoms.3. Fasting and cutting unnecessary foods can promote weight loss by reducing calorie intake and stimulating the body's fat-burning processes. It may also help regulate appetite, improve metabolism, and aid in cancer and autoimmune conditionsRESOURCES:Dr. Jenn SimmonsFollow Dr. Jenn Simmons on Instagram here. Visit Dr. Jenn Simmon’s website here. ReInvent HealthcareGet our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease. Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  
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Jun 21, 2023 • 46min

Genetics Related to Serotonin Synthesis, Reuptake, and Metabolism

In this episode of ReInvent Healthcare, we zero in on the brain and the genetics related to serotonin synthesis together with my special guest, Dr. Ben Lynch.Dr. Ben Lynch is the best-selling author of Dirty Genes and the President of Seeking Health, a company that helps educate health professionals on how to overcome genetic dysfunction. IN THIS EPISODE:Key Genes in Serotonin SynthesisSerotonin is a neurotransmitter that plays a crucial role in regulating mood, behavior, and various physiological processes. Practitioners learning about important genes related to serotonin synthesis should focus on genes such as TPH1 and TPH2, which encode the enzymes tryptophan hydroxylase 1 and 2, respectively. These enzymes are responsible for converting the amino acid tryptophan into 5-hydroxytryptophan (5-HTP), a precursor molecule in serotonin synthesis. TPH1 is primarily expressed in peripheral tissues, while TPH2 is predominantly found in the brain.Genes Involved in Serotonin ReuptakeSerotonin reuptake transporters are proteins that remove serotonin from the synaptic cleft, terminating its signaling and regulating serotonin levels. The serotonin transporter gene (SLC6A4), also known as the serotonin transporter or SERT gene, is a crucial gene in this process. Variations in the SLC6A4 gene, such as the 5-HTTLPR polymorphism, have been associated with altered serotonin reuptake efficiency and have been implicated in various psychiatric disorders and individual differences in emotional and behavioral traits.Understanding Serotonin Metabolism After serotonin is released into the synaptic cleft, it undergoes degradation by the enzyme monoamine oxidase (MAO). Two forms of MAO, MAOA and MAOB, are responsible for metabolizing serotonin. Practitioners should consider these genes when studying serotonin metabolism. Variations in the MAOA gene have been linked to altered enzyme activity and have been associated with aggression and impulsive behavior. Understanding the genetic factors influencing serotonin metabolism and the nutrient cofactors that are necessary for metabolism can provide insights into lifestyle factors and nutrients that can assist clients in managing their care.RESOURCES:Dr. Ben LynchFollow Dr. Ben Lynch on Instagram here. Check out Dr Ben’s Seeking Health website here.  If you want to learn more about Dr. Ben Lynch and check out his book, Dirty Genes, click here. ReInvent HealthcareGet our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease. Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  
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Jun 14, 2023 • 18min

Adrenal FAQs

We are on the last episode in our Adrenals theme so in this episode of ReInvent Healthcare, we go over the most commonly asked questions I get about the adrenal glands in order to help our clients and patients live optimized lives. IN THIS EPISODE:The Difference between Adrenal and Thyroid SymptomsAdrenal dysfunction is often characterized by a tired and wired presentation, with individuals experiencing tiredness at certain times of the day and an inability to turn off their racing thoughts and fall asleep. Thyroid symptoms, on the other hand, tend to be more consistent throughout the day. Other differentiating factors include blood pressure levels (low in adrenal dysfunction, high in thyroid conditions) and the presence of constipation (more common in thyroid conditions).Testing For Adrenal DysfunctionWhile blood tests can be useful for assessing thyroid function, they are not as informative for evaluating adrenal function. Fasting first morning cortisol levels, commonly measured in blood tests, don't provide a comprehensive picture of the state of the HPA (hypothalamic pituitary adrenal) axis. Alternative tests such as saliva tests and Dutch tests, which analyze cortisol levels at different times of the day and examine metabolites, can provide more valuable insights into adrenal function.Exercise Recommendations for Adrenal HealthIt's important not to overtax the system when recommending exercise for individuals with HPA axis dysfunction. Lighter forms of exercise such as stretching, yoga, swimming, walking, and light weights are generally better suited to their condition. Starting with small amounts of exercise and gradually increasing intensity based on individual tolerance is recommended. It's crucial to avoid exercises that leave them excessively exhausted and in need of several days of recovery.RESOURCES:Read through our FREE Resource Adrenal Guide.Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease. Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Watch our recorded Thyroid Adrenal Workshop here.
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Jun 7, 2023 • 34min

Fasting and Adrenal Dysfunction with Kyle Gray

In this episode of ReInvent Healthcare, we have my friend and mentor, Kyle Gray, to go along this journey of understanding the relationship between fasting and adrenal dysfunction. We tackle how it works for the adrenals, different types, and even how this can be beneficial or detrimental for certain clients. Listen to the full episode to learn more.IN THIS EPISODE:Fasting Isn’t “One Size Fits All”It is essential to conduct a thorough assessment of your clients’ adrenal function before recommending any type of fasting. This includes evaluating symptoms, conducting a thorough health history, and lifestyle assessment, and examining hormone levels and cortisol patterns as needed. Adrenal dysfunction can manifest differently in each client, and an individualized approach is necessary to determine if fasting is appropriate and how it should be implemented.How Fasting Affects CortisolFasting can lead to an increase in cortisol production because the body perceives the lack of food as a stressor and activates the stress response, triggering the release of cortisol. The rise in cortisol helps mobilize stored energy from fat and muscle tissues to maintain blood glucose levels and meet the body's energy demands. However, as the fasting period continues, cortisol levels tend to stabilize or even decrease. This response can be different for different people, so this is where it is important to know your client, ask the right questions, and listen to how your client feels. The “Low and Slow” ApproachA gentle and gradual approach to fasting in patients with adrenal dysfunction can help assess our clients better. Sudden and drastic changes in eating patterns can place additional stress on the adrenal glands, potentially worsening the dysfunction. Starting with shorter fasting periods, such as intermittent fasting with a restricted eating window, and gradually increasing the fasting window can help the body adapt more effectively and reduce the risk of triggering adrenal imbalances.RESOURCES:Kyle GrayListen to Kyle Gray’s The Story Engine Podcast here.Listen to the The Story Engine Book here.Follow Kyle Gray on Twitter.Follow Kyle Gray on LinkedIn.Visit Kyle Gray’s Website.ReInvent HealthcareRead through our FREE Resource Adrenal Guide.Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease. Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Watch our recorded Thyroid Adrenal Workshop here.
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May 31, 2023 • 16min

Genetic Factors Related To Adrenal Function

In this episode of ReInvent Healthcare, we go over the intricate connection between genetics and adrenal health, the importance of gene testing, and learning about how certain genetic variations can impact adrenal hormone production, stress resilience, and even the risk of adrenal disorders. Listen to the full episode to learn more IN THIS EPISODE:Genetic Variations and Adrenal HealthGenetic factors play a significant role in adrenal health and the functioning of the hypothalamic pituitary adrenal (HPA) axis. Understanding the genetic variations involved in adrenal function can help identify susceptibility to adrenal-related conditions and guide personalized approaches to maintaining adrenal health.SNP Variations and Adrenal DysfunctionSingle nucleotide polymorphisms (SNPs), which are genetic variations, can impact the function of adrenal hormone receptors and signaling pathways. Certain SNPs can lead to chronic fatigue, obesity, anxiety, depression, and chronic pain, indicating a tendency toward adrenal dysfunction.Importance of Stress Management and Personalized SupportGenetic variations related to adrenal health indicate a need for individuals to be more mindful of factors that affect adrenal function. Stress management techniques and personalized support, including targeted supplementation and lifestyle modifications, can help restore adrenal balance and improve overall health. The focus should be on addressing the underlying causes rather than merely covering up symptoms.RESOURCES:Read through our FREE Resource Adrenal Guide.Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease. Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Watch our recorded Thyroid Adrenal Workshop here.Join my June 2-4, 2023 Nutritional Endocrinology Symposium here.
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May 24, 2023 • 16min

Nutrients for Adrenal Dysfunction

In this episode of ReInvent Healthcare, we continue on our topic about adrenal health. For this episode, we explore the role of nutrients in managing adrenal dysfunction and dive into their significance and how they can be incorporated into your clients’ diet and lifestyle to nourish the adrenal glands and to effectively manage adrenal dysfunction. Listen to the full episode to learn more. IN THIS EPISODE:Nutrients for Adrenal DysfunctionNutrients play a crucial role in supporting optimal adrenal health. Adrenal glands, responsible for producing hormones like cortisol, require specific nutrients to function efficiently. Nutrients like vitamin C, B vitamins (particularly B5, B6, and B12), magnesium, and zinc are involved in adrenal hormone synthesis and regulation. Adequate intake of these nutrients can help maintain proper adrenal function, support stress response, and promote overall energy production. By understanding the impact of nutrients on adrenal health, we as healthcare practitioners can offer targeted dietary and supplementation recommendations to our patients, leading to improved adrenal function, reduced stress-related symptoms, and enhanced overall well-being.Important NutrientsVitamin C: Essential for adrenal hormone synthesis and helps regulate cortisol levels, promoting healthy stress response.B vitamins (B5, B6, and B12): Important for adrenal gland function and energy production. B5 helps convert cholesterol into many important hormones , B6 aids in neurotransmitter synthesis, and B12 supports nerve health.Magnesium: Plays a role in regulating cortisol levels and supports relaxation. Adequate magnesium levels can help reduce stress and promote better sleep.Zinc: Required for adrenal hormone production and assists in immune function. Zinc deficiency can lead to impaired adrenal function.Omega-3 fatty acids: Possess anti-inflammatory properties, which can reduce stress-induced inflammation and support adrenal health.Adaptogenic herbs: While not nutrients per se, adaptogenic herbs like ashwagandha, rhodiola, rosea, and holy basil can help modulate the body's stress response and support adrenal function.The Benefit of Probiotics and Fermented Foods Probiotics and fermented foods can provide several benefits for individuals with adrenal dysfunction. Some examples are for gut health support, stress response modulation, nutrient synthesis absorption, and reduced inflammation. Incorporating probiotics and fermented foods into the diet of your clients can offer support for adrenal dysfunction. RESOURCES:Read through our FREE Resource Adrenal Guide.Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease. Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.  Watch our recorded Thyroid Adrenal Workshop here.Join my June 2-4, 2023 Nutritional Endocrinology Symposium here.

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