Ego dissolution during psychedelic experiences, such as with MDMA or psilocybin, correlates strongly with trauma healing. Merely experiencing visual effects from psychedelics does not lead to significant clinical improvement. The key factor for healing is the ability to dissolve the ego. Ketamine, a dissociative agent originally developed for anesthesia, exemplifies this mechanism. Its rapid effects on major depressive disorder occur because it enables a temporary separation from the ego, which can alleviate the negative self-talk that often accompanies depression. By disconnecting individuals from their self-critical thoughts, both ketamine and psychedelics can facilitate a healing process. However, these substances should only be used under the guidance of a licensed professional.