We explore the life, work, and thought of Zosimus of Panopolis, the greatest alchemist of late antiquity, with Professor Matteo Martelli. Topics include Zosimus' birthplace and significance, his critique of priest Nils' operations, the influence of Theosebia in alchemical tradition, manuscripts and translations of Zosimus, the interpretation of alchemy and its relationship to spirituality and laboratory work, the concept of pinuma and its various meanings, and the significance of dreams in spiritual alchemy.