Yasemin Saplakoglu, a science writer at Quanta Magazine, explores the fascinating history and neuroscience of zero. She reveals how zero, first acknowledged in 7th century India, faced skepticism in medieval Europe. The discussion dives into the brain's unique processing of numbers, particularly how we comprehend nothingness versus other values. Yasemin highlights groundbreaking research on how our brain reacts to zero and the complexity of numerical cognition, showcasing the intricate relationship between absence and understanding.