Dr. Victoria Werth, Chief of Dermatology at the VA Medical Center and Professor at the University of Pennsylvania, sheds light on the role of Type I interferons in autoimmune skin diseases like cutaneous lupus and dermatomyositis. She discusses the inflammation mechanisms and skin manifestations linked to these conditions, highlighting the challenges of misdiagnosis. Dr. Werth also explores advancements in immunotherapy, the personalized use of hydroxychloroquine, and the importance of collaboration in improving lupus treatment outcomes.