In this engaging discussion, burn specialists Robel Beyene, Colonel Jennifer Gurney, and Tina Palmieri explore the innovative use of Fresh Frozen Plasma (FFP) in burn resuscitation. They delve into the historical evolution of plasma-based techniques and the critical importance of timely administration to reduce endothelial damage. The conversation highlights significant advancements and ongoing research that inform better patient care practices. Challenges in current resuscitation metrics and new strategies like enteral nutrition are also examined, shedding light on the future of burn treatment.