Historical Context of Plasma-Based Resuscitation

Plasma-based resuscitation has a long history dating back to the 1920s and 1930s, initially utilized during World Wars. Its decline in popularity was attributed to high incidences of hepatitis and adverse reactions associated with fresh frozen plasma administration, particularly due to the pooling of plasma from multiple donors. During the 1950s and 60s, crystalloid solutions became more favored as research indicated their effectiveness in resuscitating burn victims. Despite the setbacks, there is a recognition that understanding the historical context of plasma's use can inform current practices and attitudes toward its reintroduction.