Professor Stuart Tangye discusses the vital role of B cells in immune responses, focusing on antibody production and memory cell formation. The podcast also explores the interplay of immunodeficiency and autoimmunity, therapeutic targets for improving immunity, and the significance of B cells and antibodies in SARS-CoV-2 infection. Additionally, it delves into the diversity and functions of CD21 low or TBAP expressing B cells in the context of inborn errors of immunity.