Sean Wharton

Dr. Sean Wharton, a leading clinical trialist and PharmD, shares insights on the latest developments in oral GLP-1 therapies. He explains the intriguing 'snack molecule' concept that improves drug delivery and discusses the promising results of the OASIS-4 trial, showcasing significant weight loss. The conversation covers the differences between peptide and small-molecule GLP-1s and the future potential of orforglipron. They also highlight the importance of safety in new formulations and how these advances could democratize weight management.

Sean Wharton, a physician and clinical trialist renowned for his work on obesity and the STEP-UP trial, shares fascinating insights on the advancements in weight loss treatments. He discusses the significance of the higher 7.2mg dose of semaglutide, trial design intricacies, and the promising future of dual and triple therapies. The conversation highlights the barriers to healthcare access, the role of intermittent fasting in weight management, and the importance of nutrition science, particularly in addressing biases that affect dietary guidelines.

Dr. Sean Wharton, Medical Director of the Wharton Medical Clinic, speaks about anti-Black racism in healthcare. He discusses how subconscious biases in the healthcare system lead to worse health outcomes for Black communities. The importance of recognizing the unique needs of trainee and patient populations is emphasized. Jessica Goncalves, the first Black President of the Nursing Undergraduate Society at the University of Toronto, highlights the importance of diverse representation in health professions. The podcast explores the challenges faced by Black individuals in obtaining proper nutrition and healthcare, the impact of racial concordance on patient health outcomes, the importance of compassion and empathy in healthcare, unconscious biases, and the role of advocacy in bringing about change in healthcare.