Dr Russell Hepple, an expert on muscle mitochondria, discusses the importance of mitochondrial permeability in aging, ischemia-reperfusion injury, and muscle dystrophies. Topics include reactive oxygen species production during exercise, elevated calcium levels, and the role of cyclophilin D. The podcast also explores the impact of diabetes, cancer, and chemotherapy on mitochondrial function, and highlights the potential benefits of exercise in protecting muscle from damage.