Former cosmologist Dara O'Briain and Dr Alice Roberts join physicist Brian Cox and comedian Robin Ince for a witty, irreverant and unashamedly rational look at the world according to science. They'll be asking why so many comedians seem to start life as scientists, and begin their quest to put science at the heart of popular culture.

Anthropologist Alice Roberts joins Brian Cox and Robin Ince to discuss the importance of failure in science, highlighting how mistakes can lead to discoveries. They explore Darwin's theory flaws, the accidental creation of Viagra, and the challenges in drug development for global health. The podcast reflects on past failures in medicine, the impact of the COVID-19 pandemic, and the debate on exercise as a health solution.

Dr. Lydia Zeldenrust, a Middle English literature expert, and Robin Ince, a comedian and broadcaster, delve into the fascinating origins of printing in England. They discuss William Caxton's groundbreaking work in 1474 and how it shaped literary culture. The conversation reveals the surprising content of Caxton's first book and compares mythological tales to modern franchises like Marvel. They also explore the transformative effects of printing on society, including literacy and language standardization, laced with humor and historical insights.

Brian Cox and Robin Ince delve into the science of magic with comedians and experts, exploring the psychology behind magic tricks and the brain's predictive nature. They discuss the art of card magic, misdirection techniques, and the therapeutic benefits of magic. The podcast highlights the intersection of magic and science, revealing the complexities and illusions behind captivating tricks.

Astrophysicist Brian Cox and comedian Robin Ince explore what makes humans unique. Anatomist Prof Alice Roberts explains interbreeding with Neanderthals. Comedian Bill Bailey learns chimpanzee communication from Dr Jane Goodall. They discuss human brain adaptability, flaws in evolution, and the design flaw of the human eye. The podcast covers diverse topics from interbreeding to non-verbal communication, with humor and insights from experts.