Experts Stephen Ansell, Paolo Ghia, and Andrew Rawstron discuss Monoclonal B-cell lymphocytosis (MBL) as a precursor to CLL, exploring biology, classification, and early interception possibilities. They cover MBL progression, genetic similarities with CLL, B-cell receptor as an early marker, and the importance of immune system interactions for early intervention.

Experts Paolo Ghia, Susan O'Brien, Lydia Scarfò, and Othman Al-Sawaf review exciting updates in chronic lymphocytic leukemia (CLL) from EHA and ICML 2021. They discuss key clinical trials, second-generation BTKs, fixed-duration therapy, depth of response, stopping treatment, retreatment potential, progression-free survival, VTK inhibitors, akylobrutinib vs. britinib, and different CLL treatment regimens.