VJHemOnc Podcast
Monoclonal B-cell lymphocytosis: classification, biology and exploring the possibility of early interception
Mar 22, 2024
Experts Stephen Ansell, Paolo Ghia, and Andrew Rawstron discuss Monoclonal B-cell lymphocytosis (MBL) as a precursor to CLL, exploring biology, classification, and early interception possibilities. They cover MBL progression, genetic similarities with CLL, B-cell receptor as an early marker, and the importance of immune system interactions for early intervention.
09:40
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Quick takeaways
- High count MBL signifies progression to CLL, while low count MBL may relate to immunosenescence without evolving to CLL.
- Presence of B-cell receptor years before CLL diagnosis indicates its role in early cell development towards CLL, emphasizing need for early interception strategies.
Deep dives
Monoclonal B Cell Lymphocytosis Classification
Monoclonal B cell lymphocytosis (MBL) is classified based on cell counts, with high count MBL showing a progression towards chronic lymphocytic leukemia (CLL) requiring treatment. Low count MBL, on the other hand, seems more related to immunosenescence, often existing in individuals above 40 years without progressing to CLL. Genetic aberrations are shared between low and high count MBL, but high count MBL have a higher likelihood of transforming into CLL and needing treatment.
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