In this engaging discussion, Nancy Cooke, a Professor of Human Systems Engineering at Arizona State University, unpacks the urgent need for better human factors in design. She emphasizes how understanding human behavior, AI limitations, and community involvement can reshape city planning and product development. Drawing lessons from Medellin's transformative urban strategies, she advocates for inclusive design in tackling societal challenges. Cooke also shares insights from NASA on human-AI collaboration, stressing the importance of user engagement in effective problem-solving.