Matthew Baggott, Founder of Tactogen Inc., discusses entactogens like MDMA and explores their effects, mechanisms of action, and the development of new drugs. Topics include different entactogens, r-MDMA vs s-MDMA, Methalone, challenges in researching controlled substances, the 'loss of magic' phenomenon, ideal dosages, off-label medications, mental illness and society, legalizing psychedelics, creating an ecosystem for thriving with entactogens, and promoting health and well-being through legal access to psychedelics.