Entactogens, MDMA, and Bringing New Love Drugs To Market | Matthew Baggott ~ ATTMind 177

Jun 2, 2023

Matthew Baggott, Founder of Tactogen Inc., discusses entactogens like MDMA and explores their effects, mechanisms of action, and the development of new drugs. Topics include different entactogens, r-MDMA vs s-MDMA, Methalone, challenges in researching controlled substances, the 'loss of magic' phenomenon, ideal dosages, off-label medications, mental illness and society, legalizing psychedelics, creating an ecosystem for thriving with entactogens, and promoting health and well-being through legal access to psychedelics.

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Introduction

00:00 • 6min

Exploring Tactogens and their Pharmacological Properties

05:33 • 18min

Challenges and Expenses in Researching Schedule I Controlled Substances

23:10 • 2min

Understanding the Loss of Magic

24:50 • 19min

The Importance of Dosage in Drug Development and Therapy

43:57 • 16min

The Benefits and Risks of Off-Label Medications

59:34 • 16min

Addressing the Paradigm Issue of Mental Illness and Society

01:15:28 • 1min

The Challenge of Legalizing Psychedelics

01:16:36 • 23min

Creating an Ecosystem for Thriving with Entactogens

01:39:09 • 3min

Strategic Moves for Long Term Value

01:42:31 • 2min

Promoting Health and Well-being through Legal Access to Psychedelics

01:44:16 • 7min

Closing Remarks and Call to Support

01:51:11 • 3min

This episode features Matthew Baggott of Tactogen Inc. and will explore entactogens, which are drugs like MDMA, 2C-B, and Methalone.

We start with setting a basic framework for what an entactogen is and a few example drugs, before exploring the complexities in their various effects, mechanisms of action, and both the legislative and technical process of the development of novel or new entactogenic drugs.

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For links to Baggott's work, full show notes, and a link to watch this episode in video, head to bit.ly/ATTMind177

*** FULL TOPICS BREAKDOWN BELOW**

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Episode Breakdown

(0:00) Opening
(2:44) Guest Bio
(4:06) Patreon thanks | Support The Show
(5:42) Interview begins
(6:31) What is an entactogen and what does it do? | The difference between entactogens and psychedelics
(8:37) A short discussion about 2C-B
(11:47) A list of different entactogens
(15:30) r-MDMA vs s-MDMA
(19:48) Methalone, aka bk-MDMA
(21:52) 3-MMC and 4-MMC: patents, development, and legality
(23:13) Why Schedule 1 makes drug development difficult
(25:02) The qualities they are trying to design OUT of new entactogen drugs (pt1)
(26:31) “The loss of magic” with MDMA
(33:11) Serotin transporters and MDMA neuro-oxidization
(36:27) Using NAC to bring back the MDMA magic | enhanced plasticity, antioxidants, and homeostasis
(44:13) The qualities they are trying to design OUT of new entactogen drugs (pt2)
(48:52) Why we need “take home” entactogenic drugs
(53:20) Can a drug still be medicine if it’s fun, too?
(58:13) The process of justifying off-label MDMA prescriptions
(1:03:01) Will there be a moral backlash against the development of “good feel” drugs?
(1:11:10) The negative social consequences of prohibitionist law enforcement
(1:15:58) We can’t just give people psychedelics and expect society will get better
(1:18:46) Problematic moves in the psychedelic biotech industry
(1:25:01) Psychedelic Patent Trolling
(1:32:15) How Tactogen is trying to give back to psychedelic users
(1:44:16) Increasing access to health care, not just to psychedelic substances
(1:49:40) Follow-up link and contact details
(1:51:25) closing