Experts from around the globe discuss the concept and challenges of platform trials in clinical research. They explore the efficiencies, funding issues, and statistical considerations of transitioning to big team science. The role of patient groups in trial designs and the challenges of educating institutional review boards and securing funding are also highlighted.

Jan Jansen and Marion Campbell present the results of the UK-REBOA trial, investigating the use of REBOA in trauma patients. They discuss the enrollment process, data collection, and clinical trial results. The podcast also covers the importance of reducing time to hemostasis in hemorrhagic deaths and the challenges of managing blunt trauma injuries. Additionally, they explore the difficulties of intubation in children and evaluating efficacy.

Panelists discuss the dosing impacts of steroids in the COVID STEROID 2 trial, embracing Bayesian approaches in clinical trials for more nuanced interpretations, navigating complexities in trial interpretation beyond statistical significance, debating optimal dosage of dexamethasone in COVID-19 treatment, analyzing timing and effectiveness of corticosteroids in ARDS, and reflecting on the collaborative effort in advancing understanding of COVID-19 treatment.