Manu Prakash, a Stanford University bioengineering professor, is known for his innovative FoldScope, a paper microscope aimed at democratizing science. He discusses the essence of 'frugal science' and how it fosters curiosity and personal transformation. Manu highlights the importance of immersing oneself in research environments, drawing on his deep-sea experiences. He reflects on how poorly formed questions can inspire breakthroughs and shares a profound moment of solitude at sea that reshaped his understanding of nature and self.

Becca Franks and Laurie Sellars explore the unintended consequences of fish farming on marine life. They discuss how aquaculture impacts consumer perceptions and biodiversity. Manu Prakash reveals the fascinating properties of the inflatable plankton, shedding light on underwater carbon sinks. Monika Bright shares discoveries of life beneath volcanic vents, showcasing nature's resilience. Finally, Chrysa Avdellidou connects cosmic events to Earth’s history, uncovering origins of a meteor linked to a mass extinction. Each guest brings a unique perspective on life’s tenacity and challenges.