Dr. Luis Buzón, an infectious disease specialist and spokesman for the Spanish Society of Infectious Diseases, sheds light on the vital role of real-world evidence in HIV care. He emphasizes how long-term data reveal treatment effectiveness and side effects often missed in clinical trials. Buzón shares a personal connection to HIV advocacy, inspired by his father's pioneering work in Spain. The discussion highlights the importance of inclusive research to improve health outcomes and the ongoing journey towards compassionate, evidence-based care.