Edyth Parker, a researcher from Nigeria, discusses the origins of the mpox epidemic, highlighting zoonotic spillover and the need for improved genomic surveillance. Jürgen Richt, a veterinary virologist, explores the risks of H5N1 flu potentially infecting pigs, raising concerns about new viral variants. Lucy van Dorp, a geneticist, delves into ancient bacteria evolution, revealing how human activities influenced pathogen lifestyles. Together, they emphasize the urgent need for equitable global health strategies to prevent future pandemics.