

WHO Pandemic Agreement reached
May 22, 2025
Edyth Parker, a researcher from Nigeria, discusses the origins of the mpox epidemic, highlighting zoonotic spillover and the need for improved genomic surveillance. Jürgen Richt, a veterinary virologist, explores the risks of H5N1 flu potentially infecting pigs, raising concerns about new viral variants. Lucy van Dorp, a geneticist, delves into ancient bacteria evolution, revealing how human activities influenced pathogen lifestyles. Together, they emphasize the urgent need for equitable global health strategies to prevent future pandemics.
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MPOX Spillover Roots in Nigeria
- Edyth Parker's study traced MPOX's sustained human epidemic in Nigeria to a single zoonotic event in 2014.
- Genomic evidence shows the virus was circulating unnoticed for years before 2017 detection.
Antiviral Protein Helps Adaptation
- An antiviral protein called ApoBEC3 edits the MPOX genome causing mutations during sustained human transmission.
- This immune response can inadvertently help the virus adapt to humans rather than eliminating it.
Origin of Nigerian MPOX Epidemic
- The Nigerian MPOX epidemic likely originated in River State, a rapidly developing oil-rich area in the south-south.
- Population density and behavioral factors in that area may have facilitated the sustained human epidemic.