The podcast explores President Biden's last campaign and concerns about his age, along with writer Lucy Sante's memoir about transitioning in her 60s. Also, a review of Sloan Crosley's memoir on grief is featured.

Louis Theroux, a veteran interviewer, engages in a thought-provoking dialogue about personal experiences and societal issues. Author Lucy Sante shares her transformative journey through a late-life gender transition, sparked by a smartphone app. The conversation also tackles the intriguing legal question of whether killing someone in your sleep counts as murder. Themes of identity, accountability, and the complexities of family dynamics add depth to their candid discussion, revealing both personal struggles and broader ethical implications.

Carrie Brownstein, Megan Rapinoe, Lucy Sante, Kara Swisher, and Kirsten Vangsness share personal stories of identity, coming out, and self-acceptance. They discuss creativity, team collaboration, music influences, gender identity through clothing & makeup, and struggles of coming out later in life.

Belgium-born writer Lucy Sante shares her transition to womanhood at 66, reflecting on her memoir 'I Heard Her Call My Name'. She discusses the 1960s, opening up her womanhood, and her searing, no-nonsense clarity in her work. Sante's literary journey, silence before transitioning, and piercing life moments are explored.

Renowned writer, Lucy Sante, shares her late-in-life gender transition journey and new memoir. She discusses her admiration for the American Thesaurus of Slang, struggles with questioning her gender identity, and reflections on childhood experiences. Lucy also explores the influence of a poetry class on her teaching and writing style, encounters with artists, and pivotal mentors. She delves into challenges with success, feelings of inadequacy, and the impact of self-acceptance on her life.