Louis Theroux, a veteran interviewer, engages in a thought-provoking dialogue about personal experiences and societal issues. Author Lucy Sante shares her transformative journey through a late-life gender transition, sparked by a smartphone app. The conversation also tackles the intriguing legal question of whether killing someone in your sleep counts as murder. Themes of identity, accountability, and the complexities of family dynamics add depth to their candid discussion, revealing both personal struggles and broader ethical implications.

Carrie Brownstein, Megan Rapinoe, Lucy Sante, Kara Swisher, and Kirsten Vangsness share personal stories of identity, coming out, and self-acceptance. They discuss creativity, team collaboration, music influences, gender identity through clothing & makeup, and struggles of coming out later in life.

Belgium-born writer Lucy Sante shares her transition to womanhood at 66, reflecting on her memoir 'I Heard Her Call My Name'. She discusses the 1960s, opening up her womanhood, and her searing, no-nonsense clarity in her work. Sante's literary journey, silence before transitioning, and piercing life moments are explored.