Andrew Kuykendall, a doctor from Moffitt Cancer Center, and Lucia Masarova, affiliated with MD Anderson Cancer Center, dive into the complexities of polycythemia vera (PV) and essential thrombocythemia (ET). They discuss unique challenges in treating adolescent and young adult patients, emphasizing personalized treatment strategies. The duo critiques current clinical trials and advocates for collaborative research to improve outcomes. They also explore the feasibility of early interventions and the importance of defining clear treatment goals.

Experts Aaron Gerds and Lucia Masarova discuss key updates in myeloproliferative neoplasms (MPNs) presented at ASH 2022, including the MOMENTUM trial, combination approaches, and novel agents like calreticulin-targeting antibodies. They also explore advancements in fibrosis treatment, the role of immunotherapies in eliminating malignant clones, and challenges in MPN treatment for accelerated and blast phase diseases.