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VJHemOnc Podcast
MPN highlights at ASH 2022: novel agents, combinations & the role of immunotherapy
Jan 26, 2023
Experts Aaron Gerds and Lucia Masarova discuss key updates in myeloproliferative neoplasms (MPNs) presented at ASH 2022, including the MOMENTUM trial, combination approaches, and novel agents like calreticulin-targeting antibodies. They also explore advancements in fibrosis treatment, the role of immunotherapies in eliminating malignant clones, and challenges in MPN treatment for accelerated and blast phase diseases.
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Quick takeaways
- The Momentum trial showed positive outcomes in myelofibrosis patients, with maintained responses at week 48 and no new safety signals, supporting the use of Momelotinib and Danazol combination therapy.
- Combination therapies in MPNs, such as Pelobrescib and Ruxillotnib, are being explored to assess their benefits beyond spleen volume response, emphasizing the need to evaluate the trade-off between side effects and positive results.
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Key Updates from the Momentum Trial
The Momentum trial, a Phase 3 randomized trial comparing Momolotnib and Danazal in patients with myelofibrosis, demonstrated positive outcomes. The week 24 data, which assessed primary outcomes, showed maintained responses at week 48 in terms of transfusion independence, spleen volume response, and symptom burden improvement. Some non-responders at week 24 became responders by week 48, suggesting the need for longer treatment duration. The updated data also indicated no new safety signals, addressing concerns regarding safety of combination therapies.
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