In this engaging discussion, Justin Muir, a critical care pharmacist and co-author of an insightful review article on acid-base disorders, joins Judah Brown, an emergency medicine pharmacy manager also involved in the article. They dive into the complexity of interpreting acid-base status, emphasizing the stepwise approach to arterial blood gas assessment. The duo explores the nuanced treatment of metabolic acidosis and the efficacy of buffering agents like Acetazolamide. Listeners will appreciate the mnemonics and practical insights shared, enhancing their understanding of vital clinical concepts.