John C. Reilly joins Conan O’Brien to chat about Clown Ministry, iconic roles, his live show Mister Romantic, and relating to chimpanzees. Audience questions include smoothie preferences, starring in Bollywood, and terrible anniversary celebrations.

John C. Reilly, known for his Mr. Romantic show, discusses authentic comedy, intimacy in acting, reflections on his career journey, navigating the acting industry, movie roles, a humorous Bert Reynolds anecdote, and insights on acting techniques and relationships.

Tim Heidecker, John C. Reilly, Fred Armisen, and Jonathan Krisel discuss Zoom culture, the challenges of pitching a show to streaming platforms, their experience making Moonbase 8, band names through the decades, diving in the Pacific, movies in the future, COVID-19 vaccine timeline, and character development in a hilarious and entertaining podcast.