Joe Chaffin, a transfusion medicine specialist known as the 'Blood Bank Guy', dives into the complexities of transfusion reactions. He discusses the significant knowledge gap among clinicians, stressing informed consent and the urgent need for proper management of reactions like TRALI and TACO. The conversation highlights how to navigate the challenging diagnostic landscape in critical care, the importance of reporting reactions, and ensuring safety in transfusion practices. Chaffin empowers healthcare professionals to improve blood handling and increase donor awareness.