Dr. Jerry Zimmerman, Professor of Pediatrics, discusses the physiologic rationale and clinical evidence for using corticosteroids in septic shock. They explore the potential benefits and adverse effects of corticosteroids in conditions like COVID-19 and ARDS. They also discuss the use of oxandrolone for muscle protein accretion and the future of clinical research. Additionally, they cover the use of corticosteroids in adrenal insufficiency, ACTH stimulation tests, and optimal cortisol cutoffs.

Dr. Jerry Zimmerman, Professor of Pediatrics at the University of Washington and former Chief of the Division of Critical Care Medicine, discusses the use of corticosteroids in septic shock. Topics include the physiologic rationale, clinical evidence, current practice patterns, side effects, and future research. The chapter also highlights the significance of perseverance, teamwork, learning, and addressing burnout in pediatric intensive care.