Key members of ERC and RCUK, Gavin Perkins and Jasmeet Soar, discuss the new resuscitation guidelines for 2021. Topics include the importance of early recognition, bystander CPR, defibrillation, airway management, and advancements in CPR and ECMO. They also touch on the comparison of intraosys vs intravenous first approach, challenges in centralizing cardiac arrest services, and the debate around double sequential defibrillation.