Eric Verdin

Eric Verdin, M.D., a leading physician-scientist and CEO of the Buck Institute for Research on Aging, dives deep into the complexities of aging. He discusses how metabolic and immune system dysfunctions influence lifespan, focusing on NAD's declining levels and promising longevity interventions like rapamycin. The conversation also delves into practical strategies for maintaining metabolic health, including diet and exercise, while emphasizing the importance of advancing biomarker research to personalize aging care. Verdin's insights shed light on the critical connections between metabolism, immunity, and aging.

Dr. Eric Verdin, President of the Buck Institute for Research on Aging, shares his expertise on combating aging. He discusses how mitochondrial health and NAD levels play vital roles in longevity. Lifestyle interventions, including fasting and physical activity, are highlighted as key strategies. Verdin also explores emerging therapies like CD38 inhibitors that could revolutionize our approach to aging. Listeners are introduced to concepts of biological versus chronological age, emphasizing the importance of personalized health strategies for a longer, healthier life.

Dr. Eric Verdin, CEO of The Buck Institute, discusses the latest updates in longevity research including the future of anti-aging drugs, the question of whether aging is a disease, and the potential for a maximum lifespan. He also shares insights on senescence and senolytics, the impact of genetics and lifestyle on longevity, and the importance of optimizing lifestyle factors for a longer and healthier lifespan.

Eric M. Verdin Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF. Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketogenesis. He's held faculty positions at the University of Brussels, the NIH and the Picower Institute for Medical Research.  In this episode, you'll discover: (00:00) Introduction (07:32) Interventions to prolong lifespan (10:42) The role of insulin pathways in aging (16:25) HDAC inhibition by ketones (27:52) Protein activates mTOR & IGF-1 (30:28) PPAR-alpha activation facilitates benefits of a ketogenic diet (35:28) What biomarkers can predict aging? (39:38) Cellular NAD+ levels decrease with age  (52:47) Ketogenic diet safety  (56:07) Intermittent fasting as an alternative to a keto diet If you’re interested in learning more, you can read the full show notes here. Join over 300,000 people and get the latest distilled information on ketogenic diet & longevity straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Dr. Eric Verdin, CEO of the Buck Institute for Research on Aging, joins to debunk myths around longevity supplements and highlight the reality of aging. He discusses the pivotal role of the immune system in aging and how lifestyle changes can significantly enhance healthspan. Topics include epigenetic reprogramming, the limitations of self-experimentation, and the potential of digital twins in precision medicine. Dr. Verdin emphasizes that while no anti-aging supplements are proven effective, adopting healthy habits could add 30 years of vitality.