Dr. Neil Dasgupta, an emergency medicine physician and program director, and Dr. Steen Galili, an anesthesiology specialty trainee, dive into the innovative use of low-dose ketamine to enhance opioid efficacy for acute pain management. They discuss a compelling case study of a cyclist in distress and the challenges of treating pain in patients with chronic opioid use. The duo highlights the need for refined pain management strategies, the ethical complexities of patient recruitment for research, and the promise that ketamine holds in revolutionizing acute pain treatment.