David S. Pisetsky, a Professor at Duke University and lupus pathogenesis expert, dives deep into systemic lupus erythematosus (SLE). He uncovers how antinuclear antibodies and active DNA interplay to trigger inflammation. The podcast explores various immune responses, from the historical LE cell discovery to the complexities of cell death mechanisms. Pisetsky also discusses the genetic factors influencing autoimmunity and offers insights into effective scientific writing, blending storytelling with rigorous research to improve communication in the field.