Experts from around the globe discuss the concept and challenges of platform trials in clinical research. They explore the efficiencies, funding issues, and statistical considerations of transitioning to big team science. The role of patient groups in trial designs and the challenges of educating institutional review boards and securing funding are also highlighted.

Discussion on the underdog quarterbacks Brock Purdy and Taylor Heinicke facing off. Six 49ers players named to Pro Bowl. Key matchups and predictions for the game. Analysis of Niners defense and quarterback performance. Maximizing impact of running back Brian Robinson. Exploration of Niners' chances for top seed amidst injuries.

The podcast discusses the upcoming game between Tom Brady and the San Francisco 49ers, with a focus on rookie quarterback Brock Purdy making his first NFL start. Topics include key matchups, predictions for Week 14, Tom Brady's deep ball throws, offensive strategies, player injuries, and the impact of Brady facing rookie quarterbacks.