Ethan Gilsdorf, a writer and performer, shares how Dungeons & Dragons helped him navigate life’s hurdles and find empowerment. David Fajgenbaum, a physician and Castleman disease advocate, discusses his battle with illness and the transformative power of storytelling in healing. Kurt Gray, a psychology professor, delves into the hero's journey as a framework for personal growth, encouraging listeners to reshape their narratives. Together, they explore how embracing life's challenges can create meaning and resilience through our own heroic tales.

David Fajgenbaum shares his journey battling Castleman disease and how he uses AI to match existing drugs with rare diseases. The podcast discusses the challenges in finding new treatments, the lack of incentives for pharmaceutical companies, and the impact of organizations like Every Cure in accelerating cure discoveries for rare diseases.