Darren Volpe

Exploring the differential considerations and neurodegenerative aspects of rapidly progressive dementia, identifying key neurobehavioral symptoms, understanding varied etiologies, diverse symptom presentations, and in-depth look into Creutzfeldt-Jakob Disease variants and pathophysiology.

Darren Volpe, a leading clinician educator at Yale, breaks down the complexities of primary dementia syndromes. He delves into the clinical features, diagnostic tests, and treatment approaches for Alzheimer's, Lewy body, vascular, and frontotemporal dementia. The discussion highlights key aspects like tau's role in Alzheimer's and the connection between REM sleep disorders and alpha-synucleinopathies. Volpe also clarifies the implications of the APOE4 variant and reviews strategies for managing co-occurring conditions in dementia patients.