Research into very, very old DNA has made huge leaps forward over the last two decades. That has allowed scientists like Beth Shapiro to push the frontier further and further. "For a long time, we thought, you know, maybe the limit is going to be around 100,000 years [old]. Or, maybe the limit is going to be around 300,000 years," says Shapiro, Professor of Ecology & Evolutionary Biology at UC Santa Cruz. "Well, now we've been working with a horse fossil in Alaska that's about 800,000 years old." Beth's career has spanned the heyday of ancient DNA research, beginning in the late 1990s when rapid genetic sequencing technology was in its early days. She talked with Short Wave co-host Aaron Scott about the expanding range of scientific puzzles the young field is tackling — from new insights into our Neanderthal inheritance to deep questions about ecology and evolution.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Beth Shapiro, Chief Scientific Officer at Colossal Biosciences and author of How to Clone a Mammoth, dives into the thrilling world of de-extinction. She discusses the quest to resurrect iconic species like the woolly mammoth and dodo through genetic engineering and ancient DNA analysis. The ethical implications and scientific hurdles of this ambitious endeavor are explored, along with the innovative technologies fueling the revival. Plus, Beth shares humorous tales about collecting ancient DNA, showcasing the adventurous side of cutting-edge science.

As a leading expert on paleogenomics, Beth Shapiro has been hearing the same question ever since she started working on ancient DNA: "The only question that we consistently were asked was, how close are we to bringing a mammoth back to life?"In the second part of our conversation (listen to yesterday's episode), Beth tells Short Wave co-host Aaron Scott that actually cloning a mammoth is probably not going to happen. "But there are technologies that will allow us to resurrect extinct traits, to move bits and pieces of genes that might be adapted to a large animal like an elephant living in the Arctic."That is what companies like Colossal Biosciences and Revive and Restore are trying to do, with Beth's help. And she is leading the effort on another iconic extinct species, the dodo. In today's episode, how Beth Shapiro's initial work mapping the dodo genome laid the groundwork to bring back a version of it from extinction, and how the knowledge scientists gain from de-extinction could help protect species under threat now.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy