Arsheena Yassin, an ID pharmacist, and Mariya Huralska, an infectious disease fellow, both from Robert Wood Johnson University Hospital, dive into the intricacies of multidrug-resistant gram-negative infections. They discuss a compelling case study showcasing the importance of patient history for effective treatment. Innovations in rapid diagnostics and the significance of tailored antibiotic therapies based on local resistance patterns are highlighted. Moreover, they stress the need for multidisciplinary collaboration to ensure safe transitions from hospital to outpatient care.