Eileen Barrett, an expert in internal medicine and former chair of the American College of Physicians Board of Regents, joins Amanda Collar, an internal medicine intern and kratom researcher. They unpack the recreational uses of kratom, noting its methods of consumption and its potential for pain relief. The discussion dives into the regulatory challenges and health risks associated with kratom, as well as its complex role as a possible gateway substance. Emphasis is placed on improving physician-patient communication and the urgent need for further research on kratom's safety.