Former cosmologist Dara O'Briain and Dr Alice Roberts join physicist Brian Cox and comedian Robin Ince for a witty, irreverant and unashamedly rational look at the world according to science. They'll be asking why so many comedians seem to start life as scientists, and begin their quest to put science at the heart of popular culture.

Anthropologist Alice Roberts joins Brian Cox and Robin Ince to discuss the importance of failure in science, highlighting how mistakes can lead to discoveries. They explore Darwin's theory flaws, the accidental creation of Viagra, and the challenges in drug development for global health. The podcast reflects on past failures in medicine, the impact of the COVID-19 pandemic, and the debate on exercise as a health solution.

Astrophysicist Brian Cox and comedian Robin Ince explore what makes humans unique. Anatomist Prof Alice Roberts explains interbreeding with Neanderthals. Comedian Bill Bailey learns chimpanzee communication from Dr Jane Goodall. They discuss human brain adaptability, flaws in evolution, and the design flaw of the human eye. The podcast covers diverse topics from interbreeding to non-verbal communication, with humor and insights from experts.

Alice Roberts, an anatomist and archaeologist renowned for her expertise in human bones, takes listeners on a journey through the hidden narratives of skeletons from centuries past. She discusses the poignant life of a medieval anchoress and the tragic fate of sailors from the Mary Rose shipwreck. Delving into the secrets of arthritis and ancient DNA, Alice reveals how these studies connect historical health issues to today. Her exploration highlights the dark tales of the St. Bryce’s Day massacre and how bones tell powerful stories of life and death.

Professor Alice Roberts and guests discuss the extraordinary life of Queen Emma, a powerful figure in 11th-century England. They unravel her strategic marriages, political influence, and resilience through turbulent events, shedding light on her complex legacy and enduring impact on history.