Dr. Carolina Reis Oliveira and Dr. Alessandra Zonari, co-founders of OneSkin, discuss how they are using recent advances in longevity science to create peptides that target senescent cells and inflammation in aged skin. They explain their rigorous discovery process, testing lead peptide OS-1 in 3D skin models and human trials, and validating safety and efficacy to meet regulatory requirements. They also share insights into launching a science-backed skincare brand and ongoing R&D for new applications.

Dr. Alessandra Zonari, Chief Scientific Officer of OneSkin, dives into the fascinating world of skin regeneration. She discusses the critical role of collagen in youthful skin and the impact of "zombie cells" on skin health. Dr. Zonari highlights the innovative OSO-1 peptide that targets these senescent cells to boost collagen production. She emphasizes a holistic approach to skincare, including lifestyle factors, and shares intriguing insights on the biological age of skin around the eyes. Get ready for groundbreaking insights into revitalizing your skincare regimen!

In this discussion, Carolina Reis Oliveira, a skin aging expert, and Alessandra Zonari, an innovator in anti-aging skincare, delve into the science behind skin health. They highlight the importance of nutrition, particularly how sugar impacts elasticity and inflammation. The episode also examines the skin microbiome's vital role and the effectiveness of advanced ingredients like retinol and innovative peptides. Listeners will learn about the growing trend of men's skincare and the balance between sun exposure and protection for maintaining youthful skin.