In this week’s episode, Dr. Shanmugam welcomes Dr. Mary Beth Son, the senior author and corresponding author of “Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies.” This study sought to determine whether the application of different MIS-C definitions and differing disease severity in patients participating in two separate comparative cohorts underlay discrepant results. Dr. Jon Hausmann, pediatric rheumatologist and host of “ACR on Air”, joins Dr. Shanmugam and Dr. Son to add to the significant expertise on this episode, with his own in both clinical pediatric and adult rheumatology. Here, Dr. Hausmann shares further insights on integrating the published literature with pediatric treatment of MIS-C.